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  • O1B.6 Maternal cumulative exposure to extremely low frequency electromagnetic fields, prematurity and bith weight: a pooled analysis of two birth cohorts

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Reproductive Effects
O1B.6 Maternal cumulative exposure to extremely low frequency electromagnetic fields, prematurity and bith weight: a pooled analysis of two birth cohorts
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  1. Lucile Migault1,
  2. Ronan Garlantezec2,
  3. Clément Piel1,
  4. Laetitia Marchand-Martin3,
  5. Sébastien Orazio1,4,
  6. Marie Cheminat5,
  7. Cécile Zaros5,
  8. Camille Carles1,6,
  9. Elisabeth Cardis7,8,9,
  10. Pierre-Yves Ancel3,10,11,
  11. Marie-Aline Charles3,12,
  12. René de Seze13,
  13. Isabelle Baldi1,6,
  14. Ghislaine Bouvier1
  1. 1University of Bordeaux, Inserm UMR 1219 EPICENE Team, Bordeaux Population Health Research Center, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France, Bordeaux, France
  2. 2Univ Rennes, Inserm, CHU, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, F-35000, Rennes, France, Rennes, France
  3. 3Inserm U1153, Obstetric, Perinatal and Paediatric Epidemiology, Sorbonne Paris cité, ‘Risks in pregnancy’ University Hospital Department, 75014 Paris, France, Paris, France
  4. 4Registre des Hémopathies Malignes de la Gironde, Institut Bergonié, Bordeaux, France, Bordeaux, France
  5. 5Joint research unit Elfe, Ined-Inserm-EFS, 133 Boulevard Davout, 75020 Paris, France, Paris, France
  6. 6Bordeaux University Hospital, Service de Médecine du Travail et Pathologies Professionnelles, 33000 Bordeaux, France, Bordeaux, France
  7. 7Barcelona Institute for Global Health (ISGlobal), Doctor Aiguader, 88, 08003 Barcelona, Spain, Barcelona, Spain
  8. 8Universitat Pompeu Fabra Barcelona, Spain, Barcelona, Spain
  9. 9CIBER Epidemiologia y Salud Pública (CIBERESP), Madrid, Spain, Madrid, Spain
  10. 10Université Paris Descartes, 75006 Paris, France, Paris, France
  11. 11URC-CIC P1419, Cochin-Port Royal Hospital, AP-HP, F-75014 Paris, France, Paris, France
  12. 12Center for Epidemiology and Statistics Sorbonne Paris cité, INSERM UMR1153, team: early Origin of the child’s Health and Development, Paris Descartes University, Villejuif, France, Villejuif, France
  13. 13TOXI PERITOX UMR-I-01 unit, INERIS, 60550 Verneuil en Halatte, UPJV, Amiens, France, Amiens, France

Abstract

Background Data on the effects of extremely low frequency electromagnetic fields (ELF-EMF) on pregnancy outcomes are inconclusive.

Objectives To study the relation between maternal cumulative exposure to ELF-EMF during pregnancy and the risk of prematurity or small for gestational age in a pooled analysis of two French birth cohorts.

Methods Elfe and Epipage2 are both population-based birth cohorts initiated in 2011 and included 18 329 and 8400 births respectively. Health data and household, mother and child characteristics were obtained from medical records, by face-to-face interview at maternity, and completed during follow-up. A recently updated job-exposure-matrix (JEM) was used to assess cumulative exposure to ELF-EMF during three periods: 1) until 15, 2) until 28 and 3) until 32 weeks of gestation. Analyses were restricted to single live births in mainland France and to mothers with documented jobs (n=19,894). Differences in selection frame between the two cohorts were controlled using a propensity score weighting method. We used multiple imputation method to deal with missing data. Logistic regression models adjusted for the main potential confounders were used.

Results According to the period studied, 3.2% to 4% of mothers were classified as highly exposed to ELF-EMF. An increased risk of spontaneous prematurity was observed among the most exposed groups in period 2 and period 3. Overall, no consistent association with small for gestational age was found.

Conclusion This study, with substantial statistical power provides evidence of a possible association between cumulative exposure to ELF-EMF during pregnancy and the risk of spontaneous prematurity.

https://doi.org/10.1136/OEM-2019-EPI.17

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