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Overall and cause-specific mortality in a cohort of farmers and their spouses
  1. Srishti Shrestha1,
  2. Christine G Parks1,
  3. Alexander P Keil2,
  4. David M Umbach3,
  5. Catherine C Lerro4,
  6. Charles F Lynch5,
  7. Honglei Chen6,
  8. Aaron Blair4,
  9. Stella Koutros4,
  10. Jonathan N Hofmann4,
  11. Laura E Beane Freeman4,
  12. Dale P Sandler1
  1. 1 Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
  2. 2 Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
  3. 3 Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
  4. 4 Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
  5. 5 Department of Epidemiology, University of Iowa College of Public Health, Iowa City, Iowa, USA
  6. 6 Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA
  1. Correspondence to Dr Dale P Sandler, Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; sandler{at}niehs.nih.gov

Footnotes

  • Contributors SS and DPS led the data analysis and prepared the first draft of the manuscript. APK and DMU provided statistical help. CGP, LEBF and DPS were involved in data acquisition and study management. All the authors were involved in data interpretation, reviewing and editing the manuscript, and providing final manuscript approval. All contributors meet the criteria for authorship.

  • Funding This work was supported by the Intramural Research Program of the National Institute of Health, National Institute of Environmental Health Sciences (Z01-ES-049030) and National Cancer Institute (Z01-CP-010119).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study was approved by the institutional review boards of the National Institute of Environmental Health Sciences (North Carolina, protocol number 11-E-N196), the National Cancer Institute (Maryland, protocol number OH93- NC-N013), Westat (Maryland), the University of Iowa (Iowa) and Battelle Health Sciences (North Carolina). We used AHS data release AHSREL201706.00 for the analysis.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Requests for data, including the data used in this manuscript, are welcome as described on the study website (https://www.aghealth.nih.gov/collaboration/process.html). Data requests may be made directly at www.aghealthstars.com; registration is required. The Agricultural Health Study is an ongoing prospective study. The data sharing policy was developed to protect the privacy of study participants and is consistent with study informed consent documents as approved by the NIH Institutional Review Board. DPS is the NIEHS principal investigator of the Agricultural Health Study and is responsible for ensuring participant safety and privacy.

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Footnotes

  • Contributors SS and DPS led the data analysis and prepared the first draft of the manuscript. APK and DMU provided statistical help. CGP, LEBF and DPS were involved in data acquisition and study management. All the authors were involved in data interpretation, reviewing and editing the manuscript, and providing final manuscript approval. All contributors meet the criteria for authorship.

  • Funding This work was supported by the Intramural Research Program of the National Institute of Health, National Institute of Environmental Health Sciences (Z01-ES-049030) and National Cancer Institute (Z01-CP-010119).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study was approved by the institutional review boards of the National Institute of Environmental Health Sciences (North Carolina, protocol number 11-E-N196), the National Cancer Institute (Maryland, protocol number OH93- NC-N013), Westat (Maryland), the University of Iowa (Iowa) and Battelle Health Sciences (North Carolina). We used AHS data release AHSREL201706.00 for the analysis.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Requests for data, including the data used in this manuscript, are welcome as described on the study website (https://www.aghealth.nih.gov/collaboration/process.html). Data requests may be made directly at www.aghealthstars.com; registration is required. The Agricultural Health Study is an ongoing prospective study. The data sharing policy was developed to protect the privacy of study participants and is consistent with study informed consent documents as approved by the NIH Institutional Review Board. DPS is the NIEHS principal investigator of the Agricultural Health Study and is responsible for ensuring participant safety and privacy.

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