Article Text

PDF
Identifying occupationally exposed populations for lung cancer screening: it is about time
  1. Fraser Brims1,2
  1. 1 Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia
  2. 2 Curtin Medical School, Curtin University, Perth, Western Australia, Australia
  1. Correspondence to Prof Fraser Brims, Curtin Medical School, Curtin University, Perth WA 6845, Australia; fraser.brims{at}curtin.edu.au

Statistics from Altmetric.com

Lung cancer is responsible for nearly one in five of all cancer deaths in the world and is the leading occupationally related cancer type.1 Tobacco smoke exposure contributes the most significant risk although in developed countries, occupational exposures are estimated to contribute to 10%–30% of all lung cancers.1 The International Agency for Research on Cancer recognises at least 13 occupational exposures that are associated with a raised risk of lung cancer and at least 6 of these (asbestos, arsenic, radon, polyaromatic hydrocarbons, silica and nickel) may have a more than additive (ie, synergistic) risk when combined with tobacco smoke exposure.1

The National Lung Screen Trial (NLST) demonstrated a 20.0% mortality reduction for lung cancer deaths with three screening rounds using low-dose CT (LDCT) of the chest.2 However, LDCT screening for lung cancer is only effective when a high-risk population is screened. The number of lung cancer deaths prevented by LDCT is strongly related to the underlying risk of lung cancer in the population. The NLST used criteria of aged 55–74 years, at least 30 pack-year history and <15 years since quitting to identify the population at risk. The result from NLST is more remarkable considering that the lowest quintile of risk had just 1 lung cancer death prevented, compared …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles