Article Text

PDF
Original article
Usual adult occupation and risk of prostate cancer in West African men: the Ghana Prostate Study
  1. Colin Adler1,
  2. Melissa C Friesen2,
  3. Edward D Yeboah3,
  4. Yao Tettey3,
  5. Richard B Biritwum3,
  6. Andrew A Adjei3,
  7. Evelyn Tay3,
  8. Victoria Okyne3,
  9. James E Mensah3,
  10. Ann Truelove4,
  11. Baiyu Yang5,
  12. Scott P Kelly2,
  13. Cindy Ke Zhou2,
  14. Lauren E McCullough1,
  15. Larissa Pardo2,
  16. Robert N Hoover2,
  17. Ann W Hsing5,6,
  18. Michael B Cook2,
  19. Stella Koutros2
  1. 1 Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
  2. 2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
  3. 3 University of Ghana Medical School, Accra, Ghana
  4. 4 Westat Rockville, Rockville, Maryland, USA
  5. 5 Stanford Cancer Institute, Stanford School of Medicine, Palo Alto, California, USA
  6. 6 Stanford Prevention Research Center, Stanford School of Medicine, Palo Alto, California, USA
  1. Correspondence to Dr Stella Koutros, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 , USA; koutross{at}mail.nih.gov

Abstract

Objectives Established prostate cancer (PCa) risk factors include age, family history of PCa and African ancestry. Studies, mostly among highly screened, predominantly European ancestral populations, suggest that employment in certain occupations (eg, farming, military) may also have an increased risk for PCa. Here, we evaluated the association between usual adult occupation and PCa risk in Ghanaian men, a population with historically low rates of PCa screening.

Methods The Ghana Prostate Study is a case-control study of PCa that was conducted from 2004 to 2012 in 749 cases and 964 controls. In-person interviews were conducted to collect information from participants, including longest held job. Industrial hygienists classified job titles into occupational categories. Unconditional logistic regression was used to calculate ORs and 95% CIs for the association between longest held job and PCa risk (overall, aggressive (Gleason≥7)), controlling for potential confounders.

Results Risk was increased among men in management (overall PCa OR=2.2, 95% CI 1.4 to 3.2; aggressive PCa OR=2.2, 95% CI 1.3 to 3.5) and military occupations (overall PCa OR=3.4, 95% CI 1.7 to 7.0; aggressive PCa OR=3.5, 95% CI 1.5 to 8.3). Risks were also elevated for management and military-specific jobs based on 3-digit level Standard Occupational Classification definitions. Sensitivity analyses accounting for access to medical care did not show significant differences.

Conclusions Our study provides some evidence for increased risk of PCa among men in management and military occupations, which is consistent with the published literature. Additional research is needed to clarify the drivers of the associations between these occupations and PCa.

  • epidemiology
  • cancer
  • international occupational health

Statistics from Altmetric.com

Footnotes

  • Contributors All authors included on this paper fulfill the criteria of authorship.

  • Funding This study was funded by the US Department of Health and Human Services, National Institutes of Health and National Cancer Institute (Z01 CP010180-17).

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval This study was approved by institutional review boards at the University of Ghana and the US National Cancer Institute.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.