Objectives Using nationwide register data, we investigated the association between maternal and paternal perinatal employment in industries with exposure to diesel engine exhaust and risk of leukaemia and central nervous system (CNS) cancers, including certain subtypes.
Methods Children aged≤19 years and diagnosed with childhood cancer from 1968 to 2016 were identified in the Danish Cancer Registry and 25 randomly selected cancer-free controls per case were matched by age and sex. Parents were identified in the Danish Civil Registration System and employment histories were retrieved from a nationwide mandatory pension fund. The probability of exposure to diesel engine exhaust was assessed using a validated job exposure matrix. Conditional logistic regression was used for estimation of ORs, including their 95% CIs.
Results Maternal employment in industries with diesel engine exhaust exposure was associated with an increased risk of CNS cancers (OR 1.31, 95% CI 0.99 to 1.74) and of astrocytoma (OR 1.49, 95% CI 1.04 to 2.14) in offspring. The highest OR for these cancers were seen for mothers with highest probability of exposure to diesel engine exhaust. For fathers, ORs for cancers under study were close to one. No increased risks of leukaemias were found for either mothers or fathers employed in diesel industries.
Conclusions Risks were increased for CNS and astrocytoma for maternal employment in industries with diesel engine exhaust.
- childhood cancer
- parental occupational exposure
- diesel engine exhaust
- register-based study
- job-exposure matrix
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Contributors JV performed programming of data, analyses, participated in interpretation of results and wrote the manuscript. KS participated in the interpretation of results and critically reviewed the manuscript. JEH was a key participant in the design of the study, interpretation of results and critical review of the manuscript. JH was a key participant in designing the study, collection of data, programming of data, interpretation of results and supervised the writing of the manuscript.
Funding This work was partly supported by the Danish Cancer Society (74150007-FU) and US National Institutes of Health (R03ES021643).
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval The Danish Data Protection agency approved this study (ref. no. 2008-41-2639, 2014-41-3174).
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement No data are available.