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1655a Reproductive toxicity of metals: critical time of prenatal exposure
  1. Mohsen Vigeh1,2,3,
  2. Kazuhito Yokoyama2,
  3. Takehisa Matsukawa2,
  4. Katsumi Ohtani1
  1. 1Fetal, Newborn, Maternal Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  2. 2Occupational Epidemiology, National Institute of Occupational Safety and Health, Kawasaki, Japan
  3. 3Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, Tokyo, Japan


Introduction Pregnancy is a unique period of women life with an increased sensitivity to toxicants, such as heavy metals. Recently, exposure to potentially toxic metals decreased sharply in both general population and workers but, chronic exposure to low-levels remained a public health problems.

Methods We have conducted longitudinal studies to estimate effects of prenatal metal exposure on various pregnancy outcomes. Maternal whole blood (taken in the first, second, and third trimester of pregnancy) and umbilical cord blood samples were collected for blood metals measurement using ICP-MS devices. We collected participants’ characteristics information and past reproductive and medical history using a structured questionnaire. Data about various pregnancy outcomes gathered during pregnancy and at the delivery.

Result We found blood metals at the early stage of pregnancy had more significant effects on pregnancy outcomes, such as low birth weight, preterm labour, preterm rupture of the membranes, and pregnancy induced-hypertension than the subsequence trimesters, or in the umbilical cord blood. In addition, the study revealed a high rate passing metals from placenta, which could increase metals level up to twice in fetal site than the maternal blood.

Discussion The early gestation metal exposure can be induce several adverse pregnancy outcomes. Therefore, the exposure protection or screening programs for the high-level exposure female workers, should be considered before pregnancy or as early as possible, because later intervention may not prevent adverse effects.

  • Metal toxicity
  • Pregnancy

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