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1113 Pleural plaques: markers of asbestos exposure or indipendent risk factor for pleural mesothelioma? a case report
  1. Pietro Sartorelli1,
  2. Gabriele d’Hauw1,
  3. Antonietta Gerardina Sisinni1,
  4. Riccardo Romeo1,
  5. Valentina Paolucci1,
  6. Donatella Spina2
  1. 1Department of Medical Biotechnology, Unit of Occupational Medicine AOU Senese, University of Siena, Siena, Italy
  2. 2Department of Medical Biotechnology, Unit of Anatomic Pathology AOU Senese, University of Siena

Abstract

Pleural plaques (PPs) represent the most common non malignant asbestos-related disease. Currently PPs are widely referred as a marker of asbestos exposure and not as an independent risk factor for the development of asbestos-related neoplastic diseases (1). However, the association between PPs and pleural mesothelioma (PM) remains controversial, as some studies on cohorts of asbestos exposed workers have shown correlation between PPs and PM. Despite this, scientific literature is poor. Research has been focused on the relationship between PPs and lung cancer, while there is a lack of studies on the possible relationship between PPs and the development of PM.

Case presentation A clinical case of a patient affected by asbestosis and PPs with a history of occupational asbestos exposure is presented. During the follow up a PM was diagnosed at a PP.

Conclusions The widespread belief that there is no relationship between PPs and PM is not supported by a vast literature as it happens for the absence of association between PPs and lung cancer. In the patient described it is not possible to determine whether the localization of the PM at a PP is incidental or not and whether the PM can be attributed only to intense exposure or even to the presence of PPs. Similar cases may not be uncommon even if not reported in the literature.

References

  1. . Maxim LD, Niebo R, Utell MJ. Are pleural plaques an appropriate endpoint for risk analyses?Inhalation Toxicology2015;27:321–334.

  2. . Pairon JC, Laurent F, Rinaldo M, Clin B, Andujar P, et al. Pleural plaques and the risk of pleural mesothelioma. JNCI2013;105:293–301. doi:10.1093/jnci/djs513

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