Introduction As chronic disease rates are becoming more prevalent, demand for more effective healthcare programs in workplace settings are on the increase. At the same time, workers’ health examination, followed by post-examination care, is an obligation for all employers in South Korea. Thus, we evaluated the procedures of operating a comprehensive workplace healthcare program in a single manufacturing company, as well as its effect on improving cerebro-cardiovascular disease(CCVD) risk among participant workers.

Methods Employees of a single, large-scale manufacturing company with ‘D2’ (having non-occupational disease) findings by health examination in relation to CCVD risk enrolled in Workers’ Healthcare Program (WHP) and chose to participate in Health Promotion Courses (HPC), a combination of series of lifestyle intervention. After three months of WHP with or without HPC, participants underwent re-examination, and changes in health status at enrolment and at re-examination were investigated.

Results Between January 2015 to May 2017, ‘D2’ employees with high CCVD risk who chose to enrol in WHP also underwent re-examination, from which the majority (71%) also participated in the HPC. Improvement of CCVD risk indices such as blood pressure, body mass index, cholesterol and fasting glucose levels were more noticeable in HPC participants compared to non-participants, and especially in subjects who actively participated in the HPC programs.

Conclusion Operating an active, autonomous healthcare program in workplace settings showed improvement or control of CCVD risks among the participants, and participating in a comprehensive lifestyle intervention showed further attribution to effective disease prevention.