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OP I – 6 Outdoor air pollution, greenspace and incidence of adhd in saxony: a semi-individual cohort study
  1. Iana Markevych1,2,
  2. Falko Tesch3,
  3. Thomas Datzmann3,4,
  4. Marcel Romanos5,
  5. Jochen Schmitt3,4,
  6. Joachim Heinrich1,2
  1. 1LMU Munich, University Hospital, Institute and Clinic for Occupational, Social and Environmental Medicine, Munich, Germany
  2. 2Helmholtz Zentrum München – German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany
  3. 3TU Dresden, Medizinische Fakultät Carl Gustav Carus, Dresden, Germany
  4. 4National Centre for Tumour Diseases, Dresden, Germany
  5. 5University Hospital of Würzburg, Centre of Mental Health, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Würzburg, Germany


Background/aim Attention deficit hyperactivity disorder (ADHD) is a frequent mental disorder with onset in childhood and largely unknown aetiology. It has been speculated that apart of genetic and lifestyle factors, the environment could also contribute to the ADHD onset but evidence is very scarce. We investigated whether outdoor air pollution and greenspace affect ADHD incidence in children residing in Saxony.

Methods 66 823 children from the population-based statutory health insurance company AOK PLUS born between 2000 and 2004 were followed until 2014. We considered any child with at least one ICD-10-GM F90 diagnosis ever by a child/adolescent psychiatrist, neuropaediatrician or psychotherapist an ADHD case. Children’s home addresses were known up to their four-digit postal code area. Population-weighted mean values of particulate matter with diameter of less than 10 µm (PM10), nitrogen dioxide (NO2) and MODIS Normalised Difference Vegetation Index (NDVI) were calculated for 186 postal code areas. Associations with each exposure were assessed by two-level adjusted Poisson regression models.

Results 2044 children (3.06%) were diagnosed with ADHD within the observation period. Pearson correlation coefficients between PM10, NO2 and NDVI were ≥|0.80|. An increase of PM10 and NO2 by 10 µg/m³ raised the relative risk of ADHD by a factor of 1.97 [95% CI: 1.35–2.86] and 1.32 [1.10–1.58], respectively. 0.1-unit increase in NDVI decreased the relative risk of ADHD by a factor of 0.82 [0.68–0.98]. Better access to child psychiatrists was the most important confounder that increased ADHD risk across all models.

Conclusion Our results provide some evidence that environmental factors might affect ADHD. Future studies with more detailed address information and better control for confounding, in particular for socioeconomic status and parental psychopathology, should clarify whether the observed associations are true.

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