Article Text

Download PDFPDF
OP I – 5 Prenatal and postnatal exposure to air pollution and white matter microstructure in school-age children
  1. Gosia Lubczyńska1,
  2. Hanan El Marroun2,
  3. Ryan Muetzel2,
  4. Maciej Strak3,
  5. William Denault4,
  6. Gerard Hoek3,
  7. Tonya White2,
  8. Bert Brunekreef3,
  9. Henning Tiemeier2,
  10. Mònica Guxens1
  1. 1ISGlobal – Barcelona Institute for Global Health, Campus Mar, Barcelona, Spain
  2. 2Erasmus Medical Centre, Department of Child and Adolescent Psychiatry/Psychology, Rotterdam, Netherlands
  3. 3Utrecht University, Institute for Risk Assessment Sciences, Utrecht, Netherlands
  4. 4Norwegian Institute of Public Health, Department of Genes and Environment, Oslo, Norway


Background/aim Exposure to air pollution is related to brain structural variations but the relationship with white matter microstructure has not yet been established. Here, we aimed to assess whether pre- and postnatal exposure to a wide range of different air pollutants is related to white matter microstructure in school-age children.

Methods We used data from 2977 children aged 8–12 years from a birth cohort in Rotterdam, The Netherlands (2002–2006). Concentrations of nitrogen oxides, particulate matter (PM) and various components of PM were estimated at home addresses using land-use regression models for the entire prenatal period and from birth until the visit at the research centre. Diffusion tensor images were obtained during the magnetic resonance imaging session and fractional anisotropy (FA) and mean diffusivity (MD) values were computed. Deletion/substitution/addition algorithm was used to select the most predictive pollutants accounting for the covariance between them. The selected pollutants were then related to white matter microstructure, adjusting for various parental socioeconomic and life-style characteristics.

Results Overall, exposure to several air pollutants was associated with decreases in FA values and increases in MD values, which possibly indicate brain alterations. These results were consistent for both pre- and postnatal air pollution estimations, yet more profound with postnatal exposures (e.g. a decrease in FA of 0.41 [95% Confidence Interval CI: −0.78 to −0.04] and an increase in MD of 0.05 [95% CI: 0.01 to 0.10] for each 1 ng/m3 increase in polycyclic aromatic hydrocarbons (PAHs) during childhood).

Conclusion Exposure to various air pollutants during fetal life and childhood was associated with alterations in white matter microstructure in school-age children. Previous studies show that lower FA and higher MD values are associated with psychiatric and neurological disorders. Considering the ubiquity of the exposure, these results raise concern and point out the need for further research in this area.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.