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0484 Exposure to ionising radiation and risk of lymphoma subtypes: analysis of the epilymph results
  1. Pierluigi Cocco1,
  2. Matteo loi2,
  3. Qi Zhi1,
  4. G Satta1,
  5. Maris G Enna1,
  6. Nickolaus Becker3,
  7. Yolanda Benavente4,
  8. Sylvia De Sanjosé4,
  9. Lenka Foretova5,
  10. Anthony Staines6,
  11. Marc Maynadié7,
  12. Alexander Nieters8,
  13. Lydia Zablotska2
  1. 1University of Cagliari, Cagliari, Italy
  2. 2University of California, San Francisco, USA
  3. 3German Cancer Research Centre, Heidelberg, Germany
  4. 4Catalan Institute of Oncology, Barcelona, Spain
  5. 5Department of Cancer Epidemiology and Genetics, Brno, Czech Republic
  6. 6Dublin City University, Dublin, Ireland
  7. 7Dijon University Hospital, Dijon, France
  8. 8University of Freiburg, Freiburg, Germany


Introduction The association between ionising radiation and risk of solid tumours and leukaemia is well established; however, the role of low dose radiation exposure in the aetiology of lymphoma is still uncertain. We investigated the role of occupational exposure to internal and external ionising radiation in the aetiology of lymphoma and its major subtypes.

Methods Between 1998 and 2004, 2348 cases and 2465 controls from six different European countries participated in the multicentre EpiLymph case-control study. A detailed occupational history was collected by questionnaire in all participants a coded using the ISCO68 occupational and NACE industrial coding systems. Based on the same coding systems, we developed a Job Exposure Matrix (JEM) to assess probability and intensity of exposure to internal and external ionising radiation. We used unconditional logistic regression to calculate Odds Ratios and their 95% Confidence Intervals for lymphoma and its major subtypes associated with the ionising radiation exposure metrics, adjusting by age, gender, education and country.

Results Risk of lymphoma overall did not show an association with exposure to radiation either internal or external. Risk of Diffuse Large B-Cell Lymphoma (DLBCL) was elevated and did show an upward trend with intensity of exposure to external radiation (Low Intensity OR=2.1, 95%CI=0.97–4.46 and High Intensity OR=2.5, 95%CI=1.21–5.08). We did not observe any risk increase associated with internal exposure to ionising radiation.

Conclusions Our results provide limited support to the relation between external sources of ionising radiation and risk of DLBCL. We cannot exclude the possibility of bias due to the multiple comparisons we made.

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