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0400 Occupational and environmental risk factors for prostate cancer in hong kong
  1. Lap Ah Tse1,
  2. Priscilla Ming Yi Lee1,
  3. Wing Ming Ho2,
  4. Augustine Tsan Lam7,
  5. Man Kei Lee Lee7,
  6. Simon Siu Man Ng3,
  7. Yonghua He8,
  8. Ka-sing Leung4,
  9. Jennifer C Hartle5,
  10. Feng Wang1,
  11. Chi Fai Ng6
  1. 1Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong
  2. 2Department of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, China 3 Family Medicine Training Centre, Prince of Wales Hospital, Shtin, Hong Kong
  3. 3Department of Surgery, Prince of Wales Hospital, Hong Kong SAR, China 5 Guilin Medical College, Shatin, Hong Kong
  4. 4Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Kowlong, Hong Kong
  5. 5Department of Health Science and Recreation, San Jose State University, USA
  6. 6SH Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Shtin, Hong Kong
  7. 7Family Medicine Training Centre, Prince of Wales Hospital, Shatin, Hong Kong
  8. 8Guilin Medical College, Guilin, China


Objectives Influence of environmental exposures on prostate cancer remains largely unclear. We aimed to document the associations of occupational and environmental risk factors with prostate cancer in Hong Kong using a case-control study.

Methods We consecutively recruited 431 incident prostate cancer cases and 402 controls to obtain information on occupational and environmental exposures using a standard questionnaire, including smoking, dietary habits, family cancer history, night shift work, use of detergents and pesticide, and lifetime usage of food containers. We developed a new assessment tool of environmental BPA exposure and created a novel cumulative BPA exposure index (CBPAI). Odds ratio and 95% confidence interval (95% CI) was performed using multiple logistic regression analysis.

Results Family history of prostate cancer was more common in cases (9.5%) than controls (3.0%), showing an adjusted OR of 3.68 (95% CI: 1.85–7.34). Weekly consumption of deep fried food and picked vegetable was associated with an excessive prostate cancer risk by 85% (95% CI: 15%–195%) and 87% (7%–228%). Night shift work was hazardous (OR=1.76, 95% CI: 1.07–2.89) but habitual green tea drinking was protective (OR=0.56, 95% CI: 0.34–0.91). A positive exposure-response relationship with CPBAI and prostate cancer was observed.

Conclusions This study demonstrated an overall picture of occupational and environmental risk factors to prostate cancer among Hong Kong Chinese men. Furthermore, this study provided the first epidemiological evidence on carcinogenicity of BPA on human prostate thus added breakthrough data into the literature.

Funding Health and Medical Research Fund (Ref. No. 11121091), Hong Kong Special Administrative Region, China.

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