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Cancer
0379 Calculating the current burden of occupational cancers in canadian women
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  1. France Labrèche1,2,
  2. Chaojie Song3,
  3. Manisha Pahwa3,
  4. Cheryl E Peters4,5,
  5. Victoria H Arrandale3,6,
  6. Chris B McLeod7,10,
  7. Hugh W Davies7,5,
  8. Jérôme Lavoué2,8,
  9. Joanne Kim3,9,
  10. Paul A Demers3,6
  1. 1Institut de recherche Robert-Sauvé en santé et en sécurité du travail, Montreal, QC, Canada
  2. 2School of Public Health, Université de Montréal, Montreal, QC, Canada
  3. 3Occupational Cancer Research Centre, Cancer Care Ontario, Toronto, ON, Canada
  4. 4Department of Health Sciences, Carleton University, Ottawa, ON, Canada
  5. 5CAREX Canada, Simon Fraser University, Vancouver, BC, Canada
  6. 6Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
  7. 7School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
  8. 8Centre de recherche du Centre hospitalier de l’Université de Montréal, Montreal, QC, Canada
  9. 9Department of Epidemiology and Biostatistics, McGill University, Montreal, QC, Canada
  10. 10Institute for Work and Health, Totonto, ON, Canada

Abstract

Objective To estimate the attributable fraction (AF) and number of annual incident cancers among women due to occupational exposures, as part of the Canadian Burden of Occupational Cancer study.

Methods Attributable fractions, calculated with Levin’s equation, used estimates of proportions of workers ever exposed (PrE) 10–50 years before diagnosis, and point/range estimates of the exposure-cancer association from the epidemiologic literature. Numbers of attributable cancers were calculated by applying AFs to 2011 Canadian Cancer Registry data. Historical exposure was derived from CAREX Canada estimates of prevalence and level of exposure. PrE was estimated from the Canadian census, labour force survey and survival probabilities. Analyses focused on 12 carcinogens with ≥5000 exposed women.

Results The highest AF among women was for mesothelioma (AF=40%); 1.6% of lung and 2.6% of ovarian cancers were also attributed to asbestos. The largest number of attributable cancers was due to shift work, a probable cause of breast cancer (AF=2.0%–5.2%, 460–1180 cases), followed by solar radiation, with 415 skin cancers (AF=1.3%). Workplace exposure to environmental tobacco smoke (ETS) was associated with 5.8% (~60 cases) of lung cancers among never-smoking women, and radon exposure in buildings resulted in almost 80 lung cancers (AF=0.7%). AFs were overall higher for men, but similar between men and women for radon and ETS among never smokers.

Conclusion In burden studies, assessing the impact of uncertainty in exposure and risk estimates is a challenge. The impact is, however, amplified among women because estimates are derived from studies primarily on male workers.

http://dx.doi.org/10.1136/oemed-2017-104636.312

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