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  • Pleural mesothelioma and asbestos exposure: a case–control study with quantitative risk assessment—response to Marsh and Benson's letter

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Letter
Pleural mesothelioma and asbestos exposure: a case–control study with quantitative risk assessment—response to Marsh and Benson's letter
  1. Daniela Ferrante1,
  2. Dario Mirabelli2,3,
  3. Sara Tunesi1,
  4. Benedetto Terracini2,3,
  5. Corrado Magnani1,3
  1. 1 Department of Translational Medicine, Unit of Medical Statistics and Cancer Epidemiology, CPO Piemonte and University of Piemonte Orientale, Novara, Italy
  2. 2 Unit of Cancer Epidemiology, CPO Piemonte and University of Turin, Turin, Italy
  3. 3 Interdepartmental Centre G. Scansetti for Studies on Asbestos and Other Toxic Particulates, University of Turin, Turin, Italy
  1. Correspondence to Daniela Ferrante, Department of Translational Medicine, Unit of Medical Statistics and Cancer Epidemiology, CPO Piemonte and University of Piemonte Orientale, V. Solaroli 17, Novara 28100, Italy; daniela.ferrante{at}med.uniupo.it

https://doi.org/10.1136/oemed-2016-104091

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    Marsh and Benson1 commented on our paper and the associated correspondence with Boffetta highlighting two issues.2–4

    First, they questioned our exposure–response analyses because we had not always used the same reference categories. We repeated all secondary analyses reported in our online supplementary tables S1 and S2 by using the same reference as in our main analysis (table 1). Risk estimates by exposure category are consistent with our main analysis results (see table 2 of our paper), confirming the exposure–response trend for pleural malignant mesothelioma irrespective of the route of exposure (occupation or environment). Owing to space constraints, we are only showing our new results for occupational and environmental exposures, but …

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    Footnotes

    • Funding The Casale case–control study was supported by a grant from Regione Piemonte, Ricerca Sanitaria Finalizzata 2004 (to CM) and by the Regione Piemonte, Ricerca Scientifica Applicata 2003 (to DM, CM). Analyses for the present study were supported by the Italian National Institute of Health—ISS, ‘Progetto Amianto’ (to CM).

    • Competing interests DM and CM acted as expert witnesses for the public prosecutor in criminal trials on asbestos-related cancers.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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