Introduction The objective is to study the association between occupational exposures and breast cancer risk in the framework of the population based multicase-control study (MCC-Spain).
Methods 1622 breast cancer cases and 1557 population controls from the MCC-Spain study were recruited in 10 Spanish regions between 2008 and 2013. Occupational history was collected for all subjects, and occupations were coded according to the Spanish National Classification of Occupations 1994 (CNO-94). The Spanish Job Exposure Matrix (MatEmESp) was applied to assess occupational exposures to different agents. Unconditional logistic regression was applied, adjusting for age, region, education and menopausal status, showing Odds Ratios and 95% Confidence Intervals (OR; CI).
Results Based on the CNO-94, plastic product workers (OR = 3.4; 1.3–8.5) and occupations related to building caretaking and cleaning (OR = 1.5; 1.2–1.9) have an increase risk in breast cancer. Breast cancer risk was associated with exposure to pesticides (OR = 1.5; 1.1–1.9), organic dusts such as paper dust and wood dust (OR = 1.3, 1.0–1.7), for both menopausal and postmenopausal women. Flour dust was associated overall and specifically for postmenopausal women. Also, welding fumes and exposure to detergents has been observed to increase breast risk. For solvents, associations were observed for formaldehyde, methylene chloride, aromatic hydrocarbons and other organic solvents only in postmenopausal women. Further analyses will be presented taking into account duration and intensity of exposure.
Conclusions Several occupational exposures were associated with an increased risk of breast cancer.
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