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P056 Occupational exposure to metals and risk of breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-spain case control study
  1. Angela Zumel1,2,3,
  2. Juan Alguacil3,4,
  3. Laura Costas3,5,
  4. Esther García1,2,3,
  5. Miguel Santibáñez6,
  6. Nuria Aragonés3,7,8,
  7. Beatriz Pérez-Gómez3,7,9,
  8. Tania Fernández-Villa10,
  9. Javier Llorca3,6,
  10. Victor Moreno3,5,11,
  11. Mikel Azpiri3,12,
  12. Marcela Guevara3,13,14,
  13. Silvia de Sanjosé3,5,
  14. José J Jiménez-Moleón3,15,16,
  15. Guillermo Fernández-Tardón17,
  16. Rocío Capelo4,
  17. Rosana Peiró3,18,
  18. Rafael Marcos-Gragera3,19,
  19. Jose María Huerta20,21,3,
  20. Gemma Castaño-Vinyals1,2,3,22,
  21. Marina Pollán3,7,8,
  22. Ana María García23,
  23. Manolis Kogevinas1,2,3,22,24
  1. 1ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
  2. 2Universitat Pompeu Fabra (UPF), Barcelona, Spain
  3. 3CIBER Epidemiología Y Salud Pública (CIBERESP), Barcelona, Spain
  4. 4Centro De Investigación en Salud Y Medio Ambiente (CYSMA), Universidad De Huelva, Huelva, Spain
  5. 5IDIBELL-Catalan Institute of Oncology, L’Hospitalet De Llobregat, Barcelona, Spain
  6. 6Universidad De Cantabria, Santander, Spain
  7. 7National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
  8. 8Instituto De Investigación Sanitaria (IIS) Puerta De Hierro, Majadahonda, Madrid, Spain
  9. 9Cancer Epidemiology Research Group, Oncology and Haematology Area, IIS Puerta De Hierro, Madrid, Spain
  10. 10Universidad De León, León, Spain
  11. 11Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
  12. 12Subdirección De Salud Pública De Gipuzkoa, Donostia, Spain
  13. 13Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
  14. 14Navarra Public Health Institute, Pamplona, Spain
  15. 15Department of Preventive Medicine and Public Health, Universidad De Granada, Granada, Spain
  16. 16Instituto De Investigación Biosanitaria De Granada, Servicio Andaluz De Salud/Universidad De Granada, Granada, Spain
  17. 17Universidad De Oviedo, Oviedo, Spain
  18. 18Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana FISABIO–Salud Pública, Valencia, Spain
  19. 19Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Girona, Spain
  20. 20Department. of Epidemiology/Murcia Health Authority, IMIB-Arrixaca, Murcia, Spain
  21. 21Universidad De Murcia, Murcia, Spain
  22. 22IMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain
  23. 23Universidad De Valencia, Valencia, Spain
  24. 24National School of Public Health, Athens, Greece


Arsenic, cadmium, chromium, and nickel are classified by IARC as human carcinogens (Group 1), while lead as a probable/possible carcinogen to humans (Group 2A). We explored associations between occupational exposure to metals and breast, chronic lymphocytic leukaemia (CLL), colorectal, prostate, and stomach cancer in the MCC-Spain population based case-control study.

Methods The analyses were based on 3047 controls, and 1499 breast, 1539 colorectal, 332 CLL, 1070 prostate, and 382 stomach cancer cases. Occupational exposure to arsenic, cadmium, chromium, iron, lead and nickel was assessed using the MatEmEsp job-exposure matrix. Logistic regression models accounting for education, sex, geographic area, number of jobs, body mass index (colorectal, prostate), smoking (stomach, colorectal), menopause (breast) and number of alive children (breast) were fit to estimate Odds Ratios (OR) and 95% Confidence Intervals (95% CI).

Results Occupational exposure to each of the studied metals was associated with higher prostate cancer risk. Associations were specially observed for a duration higher than 10 years, and among those working in occupations with higher probability*intensity of the exposure. Working in occupations entailing higher probability*intensity of the exposure to cadmium, chromium and nickel was associated with breast cancer. Arsenic exposure for more than 10 years showed a non-significant higher risk of colorectal cancer. None of the metals assessed showed any suggestion of an association with CLL, nor stomach cancer.

Our results support the association between occupational exposure to carcinogenic metals and risk of hormone related tumours like breast and prostate cancer.

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