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P030 Animal production and risk of lympho-hematopoietic cancers in three cohort studies of farmers within the agricoh consortium-preliminary results
  1. Sonia El-Zaemey1,
  2. Leah Schinasi2,
  3. Gilles Ferro1,
  4. Isabelle Baldi3,4,5,
  5. Séverine Tual6,7,
  6. Pierre Lebailly6,7,9,
  7. Karl-Christian Nordby9,
  8. Kristina Kjaerheim10,
  9. Joachim Schüz1,
  10. Alain Monnereau11,
  11. Maartje Brouwer12,
  12. Hans Kromhout12,
  13. Maria Leon1,
  14. Laura E Beane Freeman13
  1. 1Section of Environment and Radiation, International Agency for Research on Cancer (IARC), France
  2. 2Department of Environmental and Occupational Health, School of Public Health, Drexel University, Philadelphia, USA
  3. 3Equipe Santé Travail Environnement, Centre De Recherche INSERM U897, University Bordeaux Segalen, ISPED Case 11, Bordeaux, France
  4. 4INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France
  5. 5CHU De Bordeaux, Service De Médecine Du Travail, Bordeaux, France
  6. 6INSERM, UMR1086-Cancers Et Préventions, Caen, France
  7. 7University Caen Basse-Normandie, France
  8. 8Centre De Lutte Contre Le Cancer François Baclesse, Caen, France
  9. 9Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health (STAMI), Oslo, Norway
  10. 10Department of Research, Cancer Registry of Norway, Oslo, Norway
  11. 11Registre Des Hémopathies Malignes De La Gironde, Institut Bergonié, 33076 Bordeaux, France; Inserm, Centre De Recherche U1219, Équipe EPICENE (Epidemiology of Cancer and Environmental Exposure), ISPED, France
  12. 12Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, The Netherlands
  13. 13Occupational and Environmental Epidemiology Branch, National Cancer Institute (NCI), Bethesda, USA


Objectives Animal farming entails a variety of exposures to infectious agents, endotoxins and pesticides, which may play a role in the aetiology of lympho-hematopoietic cancers. The aim of this investigation was to assess lymph-hematopoietic cancers risk in association with raising animals on farms.

Method Self–reported animal production (cattle, hogs, sheep/goats, poultry) were collected in the US Agricultural Health Study, French Agriculture and Cancer Study, and Cancer in the Norwegian Agricultural Population cohorts. Associations with risk of lymph-hematopoietic cancers, including 18 cancer outcomes, were evaluated using Cox proportional hazard models, adjusted for sex, pesticides and other confounders. The referent category consisted of farmers who didn’t produce the animal species being evaluated. Cohort-specific hazard ratios (HR) were combined using random effects meta-analysis. Among 316,270 farmers, 3,282 lymph-hematopoietic cancers were diagnosed between 1993–2011.

Results 60%, 35%, 33%, and 27%, of farmers raised cattle, hogs, poultry and sheep/goats, respectively, although the prevalence varied by cohort. Raising cattle was not associated with overall non-Hodgkin lymphoma (meta-HR=1.04; 95% Confidence Interval (CI): 0.93–1.16; I2 = 13%), but was associated with follicular lymphoma (meta-HR = 1.43; 95% CI: 1.02–2.01; I2 = 21%). The risk of myelodysplastic syndromes was significantly reduced in farmers who raised sheep/goats (meta-HR = 0.66; 95% CI: 0.46–0.95; I2 = 0%), as was the risk of „marginal-zone lymphoma among farmers who raised hogs (meta-HR = 0.57; 95% CI: 0.33–0.99; I2 = 0%), with the majority of exposed cases coming from two cohorts. We observed no meta-association between raising poultry and any lymph-hematopoietic cancer subtypes. It should be noted that differences in raising animals between countries and years might have influenced relevant exposures and therefore HR estimates for lymph-hematopoietic cancer sub-types might vary by cohort for specific animals.

Conclusions This study suggests specificity of associations between specific animals raised and lymph-hematopoietic cancer sub-types. These associations will be investigated further considering number of animals raised and farmers producing single species.

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