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  • P021 Heat working environment and risk of breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-spain case control study

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Cancer
P021 Heat working environment and risk of breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-spain case control study
  1. Miguel-Angel Alba-Hidalgo1,
  2. Juan Alguacil1,2,
  3. Laura Costas2,3,
  4. Esther Gracia2,4,
  5. Juan-Antonio Garrido1,
  6. Nuria Aragonés2,5,6,
  7. Beatriz Pérez-Gómez2,5,
  8. Antonio-José Molina7,
  9. Javier Llorca2,8,
  10. Víctor Moreno3,
  11. Jone-Miren Altzibar9,
  12. Rosana Burgui2,10,
  13. Silvia de Sanjose2,3,
  14. José-Juan Jiménez-Moleón2,11,12,
  15. Guillermo Fernández-Tardón13,
  16. Rocío Capelo1,
  17. Rosana Peiró2,14,
  18. Rafael Marcos-Gragera2,16,
  19. María-Dolores Chirlaque17,
  20. Gemma Castaño-Vinyals2,4,
  21. Marina Pollán2,5,
  22. Ana-María García16,
  23. Manolis Kogevinas2,4
  1. 1Research Centre of Health and Environment (CYSMA), University of Huelva, Huelva, Spain
  2. 2CIBER Epidemiología Y Salud Pública (CIBERESP), Madrid, Spain
  3. 3Institut Català d’Oncologia (ICO), L’Hospitalet De Llobregat, Barcelona, Spain
  4. 4Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
  5. 5National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
  6. 6Instituto De Investigación Sanitaria (IIS) Puerta De Hierro, Majadahonda (Madrid), Spain
  7. 7University of León, León, Spain
  8. 8University of Cantabria, Santander, Spain
  9. 9Subdirección De Salud Pública De Gipuzkoa, Donostia, Spain
  10. 10Navarra Public Health Institute, Pamplona, Spain
  11. 11Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
  12. 12Instituto De Investigación Biosanitaria De Granada Servicio Andaluz De Salud/Universidad De Granada, Granada, Spain
  13. 13Oncology Institute (IUOPA), University of Oviedo, Oviedo, Spain
  14. 14Fundación Para El Fomento De La Investigación Sanitaria Y Biomédica De La Comunitat Valenciana FISABIO–Salud Pública, Valencia, Spain
  15. 15Epidemiology Unit and Girona Cancer Registry, Catalan Institute of Oncology, Barcelona, Spain
  16. 16University of Valencia, Valencia, Spain
  17. 17Department of Epidemiology, Murcia Regional Health Authorit, Murcia, Spain

Abstract

Occupational exposure to heat can affect the absorption of carcinogenic chemicals into the body, and the metabolism of sexual hormones. We explored the association between occupational exposure to heat and breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-Spain population based case-control study.

Methods The analyses were based on 3047 controls, and 1499 breast, 1539 colorectal, 332 LLC, 1070 prostate, and 382 stomach cancer cases. Heat working environment from either natural or artificial sources was assessed with the MatEmEsp job-exposure matrix. Logistic regression models accounting for education, sex, geographic area, BMI (colorectal, prostate), smoking (stomach, colorectal), menopause (breast) and number of alive children (breast) were fit to estimate Odds Ratios (OR) and 95% Confidence Limits (95 CL).

Results Prostate cancer risk was over two and a half fold higher among men working for more than 10 years on a heat working environment than among who did not. Women working more than 10 years in occupations entailing heat exposure showed a higher risk of having breast cancer (OR: 1.3, 95% CL 1.04–1.7). The same figures where obtained for those working in occupations with higher probability*intensity of the exposure. Significant higher risk associations were also observed for colorectal cancer, among both men and women separately. While for stomach cancer, statistical significance was obtained only among men. LLC showed a suggestion of an association for both men and women.

Our results provide further support to the hypothesis that working in a heat environment might be a risk factor for chemically and hormone related cancers.

https://doi.org/10.1136/oemed-2016-103951.346

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