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Authors' reply to letters from Egilman et al and Oliver et al
  1. Julian Peto1,
  2. Clare Gilham1,
  3. Christine Rake1,
  4. Andrew Darnton2,
  5. John Hodgson2,
  6. Garry Burdett3
  1. 1 London School of Hygiene and Tropical Medicine, London, UK
  2. 2 Health and Safety Executive, Bootle, UK
  3. 3 Health and Safety Laboratory, Buxton, UK
  1. Correspondence to Professor Julian Peto, Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK; julian.peto{at}

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Dr Egilman and colleagues claim our report1 implies that chrysotile does not cause mesothelioma. So did the International Chrysotile Association, the website of which highlighted our paper with the misleading headline ‘reliable scientific data confirms negligible role of chrysotile in UK patients with asbestos-related lung disease’.2 Our results are consistent with the strong evidence that chrysotile did not cause a large proportion of UK mesotheliomas, but they certainly do not show that the risk is negligible. We said ‘the rapid clearance of chrysotile from the lung with a half-life of a few months explains its virtual absence in our samples, and implies that we cannot estimate its effects except by noting that amphibole lung burdens account very well for mesothelioma incidence’. In relation to lung cancer, we said, ‘the contribution of chrysotile to current UK lung cancer rates is not known and may be impossible to ascertain’. Uncontrolled chrysotile use caused large lung cancer and asbestosis risks, and its abandonment by Europe and many other countries stimulated development of novel alternatives rather than causing economic damage. These are sufficient grounds for worldwide replacement of chrysotile with safer substitutes. The mesothelioma risk, although less, reinforces the case.

Dr Egilman and colleagues also criticise our analysis of lung rather than pleural tissue and our restriction of transmission electron microscope (TEM) counting to asbestos fibres longer than 5 μm. We observed that ‘for fibres of specified dimension it seems reasonable to assume a linear relationship between inhaled dose, fibre concentration in pleural stomata and our measurements in lung parenchyma’. After reviewing the human, animal and in vitro evidence, an expert panel convened by the US Agency for Toxic Substances and Disease Registry concluded that ‘There is a strong weight of evidence that asbestos and synthetic vitreous fibers shorter than 5 μm are unlikely to cause cancer in humans’.3 Our protocol for anonymised sample preparation used minimal ultrasonic treatment and did not involve freezedrying, and we used a single laboratory. They cite the assumption in 1978 that mesotheliomas in the Rochdale factory were caused by chrysotile.4 This predated the admission by the company that over 10 000 tonnes of crocidolite were also processed between 1932 and 1968.5

Dr Oliver and colleagues missed several details. There were no next-of-kin or proxy interviews, our statistical definition of asbestos-related lung cancer did not involve asbestosis (which would be biased) and we showed that our estimated ratio of mesothelioma to asbestos-related lung cancer is consistent with two population-based UK studies. That ‘the gold standard for asbestos-exposure assessment is the occupational history, not fiber burden’ is contradicted by the dose–response we observed within occupational groups and is particularly unhelpful in relation to Britain's high mesothelioma rate in both sexes due to environmental asbestos exposure from unidentified sources.6 The strong correlation we observed between lung burden and mesothelioma risk will not ‘imperil the diagnosis of asbestos-related disease, victim compensation, and public health measures aimed at primary and secondary prevention’. Our results, together with lung burdens in younger people, will enable the risks associated with current exposures from asbestos in buildings to be estimated, informing effective disease prevention.


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  • Funding Health and Safety Executive, British Lung Foundation and Cancer Research UK.

  • Competing interests None declared.

  • Ethics approval South Thames Multicentre Research Ethics Committee.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Open Access This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See:

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