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Original article
Cross-shift study of exposure–response relationships between bioaerosol exposure and respiratory effects in the Norwegian grain and animal feed production industry
  1. Anne Straumfors1,
  2. Kari Kulvik Heldal1,
  3. Wijnand Eduard1,
  4. Inge M Wouters2,
  5. Dag G Ellingsen1,
  6. Marit Skogstad3
  1. 1Department of Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway
  2. 2Faculty of Veterinary Medicine, Institute of Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
  3. 3Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway
  1. Correspondence to Dr Anne Straumfors, Department for the Chemical and Biological Work Environment, National Institute of Occupational Health, P.O. Box 8149 Dep, Oslo 0033, Norway; anne.straumfors{at}stami.no

Abstract

Objective We have studied cross-shift respiratory responses of several individual bioaerosol components of the dust in the grain and feed industry in Norway.

Methods Cross-shift changes in lung function and nasal congestion, as well as in respiratory and systemic symptoms of 56 exposed workers and 36 referents, were recorded on the same day as full-shift exposure to the inhalable aerosol fraction was assessed. Exposure–response associations were investigated by regression analysis.

Results The workers were exposed on average to 1.0 mg/m3 of grain dust, 440 EU/m3 of endotoxin, 6 µg/m3 of β-1,3-glucans, 17×104/m3 of bacteria and 4×104/m3 of fungal spores during work. The exposure was associated with higher prevalence of self-reported eye and airway symptoms, which were related to the individual microbial components in a complex manner. Fatigue and nose symptoms were strongest associated with fungal spores, cough with or without phlegm was associated with grain dust and fungal spores equally strong and wheeze/tight chest/dyspnoea was strongest associated with grain dust. Bioaerosol exposure did not lead to cross-shift lung function decline, but several microbial components had influence on nose congestion.

Conclusions Exposure to fungal spores and dust showed stronger associations with respiratory symptoms and fatigue than endotoxin exposure. The associations with dust suggest that there are other components in dust than the ones studied that induce these effects.

  • acoustic rhinometry
  • gas diffusion
  • microbial components
  • spirometry

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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