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0271 The change of oxidative DNA damage in nurses with shift work
  1. Pei-Chen Lin1,
  2. Hsin-Chia Hung2,
  3. Shung-Mei Pan3,
  4. Ming-Tsang Wu1,4
  1. 1Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung City, Taiwan
  2. 2Department of Nursing, Meiho University, Pingguang, Taiwan
  3. 3Department of Nursing, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan
  4. 4Center of Environmental and Occupational Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung City, Taiwan


Objectives To investigate the change of concentration of 8-hydroxy-2’-deoxyguanosine (8-OHdG) at different work time among shift work nurses.

Method A total of 51 nurses with regulated rotation shift in medical centre or district hospital. Urinary concentrations of 8-OHdG, a biomarker of oxidative DNA damage, were measured. According the rotation schedule, like 1–2 days off - 2day shifts-2evenning shifts- 2night shifts, the urine was collected at 4 time points. The 2 workdays on the last day shift and last night shift of a shift course were selected and urine was collected at work before and finished work after on assigned workday, separately.

Results The urinary concentrations of 8-OHdG at work after was significantly higher than at work before on the end of day shift (paired t test, p-value: 0.0363). The concentrations of 8-OHdG between at work after and work before on the end of nigh shift were not significantly different (paired t test, p-value: 0.1673). Besides, there was no difference on the concentrations of 8-OHdG at work after between a day shift and a night shift. We also found that the change of concentrations of 8-OHdG at a day shift was significantly different on work institution (p-value: 0.0009).

Conclusions We found the more change of concentration of 8-OHdG was at a day shift work then a night shift work, even night shift was as a risk factor of health.

Therefore, the change of concentration of 8-OHdG was as a biomarker to respond the workload exposure.

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