Article Text

Download PDFPDF

0087 Long-term day-and-night rotating shift work poses a barrier against the normalisation of liver function
  1. Yu-Cheng Lin1,2,
  2. I-Chun Hsieh3,
  3. Pau-Chung Chen2
  1. 1En Chu Kong Hospital, Department of Occupational Medicine, New Taipei, Taiwan
  2. 2Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan
  3. 3Taiwan Adventist Hospital, Environmental and Occupational Medicine, Taipei, Taiwan


Objectives To evaluate the impact of day-and-night rotating shift work (RSW) on liver health, we analysed the association between long term RSW exposure and the normalisation of plasma alanine transaminase (ALT) levels over a five-year period.

Method The data from physical examinations, blood tests, abdominal sonographic examinations, personal histories, and occupational records were collected from a cohort of workers in a semiconductor manufacturing company. The sample population was divided into three subgroups for analysis: persistent daytime workers, workers exposed intermittently to RSW (i-RSW), and exposed to persistent RSW (p-RSW).

Results Records were analysed for 1196 male workers with an initial mean age of 32.5 years (SD 6.0 years), of whom 821 were identified as rotating shift workers, including 374 i-RSW and 447 p-RSW workers. At the beginning of the follow-up, 275 were found to have elevated ALT (e-ALT): 25.1% day-time workers, 23.0% i-RSW workers and 21.3% p-RSW workers. Of those with e-ALT at the beginning, 101 workers showed normalised serum ALT levels at the end of five-year follow-up: 10.7% of day-time workers, 8.6% of i-RSW workers, and 6.5% of p-RSW workers; P = 0.016). By performing multivariate logistic regression analyses, and comparing with the persistent daytime co-workers, after controlling for confounding variables, analysis indicated that the workers exposed to p-RSW were 46% less likely (OR, 0.54; 95% CI, 0.30–0.95; P = 0.03) to attain normal ALT levels within a five-year interval.

Conclusions Persistent day-and-night RSW pose a vigorous obstacle to the normalisation of e-ALT among workers with preexing abnormal liver function.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.