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0058 Colorectal cancer risk and shift work in a population-based case-control study in Spain (MCC-Spain)
  1. Kyriaki Papantoniou1,2,
  2. Manolis Kogevinas1,2,
  3. Vicente Martin Sanchez2,3,
  4. Victor Moreno2,4,
  5. Marina Pollan2,5,
  6. Jose Juan Jimenez Moleón2,6,
  7. Eva Ardanaz2,7,
  8. Jone MAltzibar2,8,
  9. Rosana Peiro2,9,
  10. Adonina Tardon2,10,
  11. Juan Alguazil2,11,
  12. Carmen Navarro2,12,
  13. Ines Gomez-Acebo2,13,
  14. Gemma Castano-Vimyals1,2
  1. 1Centre for Research in Environmental Epidemiology (CREAL, Barcelona, Spain
  2. 2CIBER Epidemiologia Y Salud Publica (CIBERESP), Madrid, Spain
  3. 3Universidad de León, Leon, Spain
  4. 4Catalan Institute of Oncology, Hospitalet, Spain
  5. 5Centro Nacional de Epidemiología-Instituto de Salud Carlos III, Madrid, Spain
  6. 6Universidad de Granada, Granada, Spain
  7. 7Servicio Navarro de Salud-Instituto de Salud Publica de Navarra, Pamplona, Spain
  8. 8Subdirección de Salud Pública de Gipuzkoa, Donostia, Spain
  9. 9Centre for Research in Public Health, Valencia, Spain
  10. 10Instituto Universitario de Oncología, Universiidad de Oviedo, Oviedo, Spain
  11. 11Universiidad de Huelva, Huelva, Spain
  12. 12Servicio Epidemiología, Consejería Sanidad, Murcia, Spain
  13. 13Universidad de Cantabria, Santander, Spain


Objectives Epidemiological cancer studies on shift work have focused on breast cancer while evidence on other tumours is limited. We evaluated colorectal cancer risk in relation to night and rotating shift work and genetic variation, in a population based case-control study in Spain.

Method 1066 male and 592 female incident colorectal cancer cases and 3388 randomly selected population controls of both sexes, enrolled in 11 regions of Spain, were included. Information was collected on socio-demographic, lifestyle, medical history and other variables by face-to-face interviews. Lifetime occupational history on daily time schedule of each job, day/night/rotating shifts, light at night exposure, and duration of different jobs, was used for exposure assessment. We used unconditional logistic regression adjusting for potential confounders.

Results Among controls 10% of males and 4% females had ever worked full time in permanent night shifts (working between midnight and 6am) and 24% of males and 14% of females in rotating shifts for ≥1 year. Having ever performed rotating shift work was associated with an increased risk for colorectal cancer (adjusted Odds Ratio 1.33, 95% CI 1.15–1.55) compared to permanent day workers. ORs increased with cumulative years of rotating shift work and the OR for more than 30 years work 1.54 (1.22–1.94). Having ever worked in permanent night shift was not associated with colorectal cancer risk. Analysis on gene-environment interactions with genes in circadian, melatonin and sleep pathways are ongoing and will be presented.

Conclusions In this large population based study we found an increase in colorectal cancer risk associated with rotating shift work.

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