Objectives This study was conducted to compare the cancer incidence in inorganic lead exposed workers with the Korean general population, and to explore the relationship between cancer mortality and blood lead levels.
Method Using from the Korean annual medical surveillance for exposure to lead, a cohort comprising 74 659 inorganic lead exposed workers working between January 1st, 2000 and December 31st, 2004 was compiled. This cohort was merged with the Korea National Central Cancer Registry (KNCCR) and death registry of the Korea National Statistical Office (KNSO) in order to evaluate the cancer morbidity for these workers between 2000 and 2008.
Results There were 793 cases cancer and, the incidence of stomach cancer (SIR 1.17, 95% CI=1.01–1.36) was found to be elevated in lead chromate workers. Excesses were observed for kidney (2.15. 1.19–3.88) and bladder cancers (2.29. 1.149–4.58) in lead exposed workers ≥20 years of job duration., kidney cancer (2.25. 1.21–4.18) in workers with ≥10 ug/dl of blood lead level and lung cancer in female workers with ≥10 ug/dl. Workers with≥40 ug/dl of blood lead levels had a significantly higher risk of overall cancer mortality (RR: 2.75; 95% CI: 1.06–1.98) compared with workers who had less than 10 ug/dl.
Conclusions Our study showed incidence excess of lung cancer in female workers, stomach cancer in lead chromate exposed workers and a possible dose-response relationship between d kidney cancers and lead exposure. Also overall cancer mortality excess was observed in high lead exposed workers.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.