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0309  Burden of cancer attributable to occupational diesel engine exhaust exposure in Canada0309  Burden of cancer attributable to occupational diesel engine exhaust exposure in Canada
  1. Joanne Kim1,
  2. Cheryl E Peters2,
  3. Chris McLeod2,
  4. Sally Hutchings3,
  5. Lesley Rushton3,
  6. Manisha Pahwa1,
  7. Paul A Demers1,4
  1. 1Occupational Cancer Research Centre, Toronto, ON, Canada
  2. 2University of British Columbia, Vancouver, BC, Canada
  3. 3Imperial College London, London, UK
  4. 4University of Toronto, Toronto, ON, Canada


Objectives To estimate the number of new lung cancers cases in Canada attributable to occupational diesel engine exhaust (DEE), which IARC classified as a definite human carcinogen in 2012. This is part of a larger effort to estimate the current burden of occupational cancers in Canada.

Method Relative risks were selected from two recent studies of miners and truckers with quantitative exposure-response. CAREX Canada estimates of exposure prevalence and level by detailed industry and occupation were supplemented by a literature search for DEE measurement data. For each exposure group, RRs were assigned based upon the estimated mean exposure. Employment trends of industries and occupations were based upon census data from multiple years. Annual Labour Force Survey data were used to attribute age- and tenure-distribution, as well as short-term turnover characteristics. Survival was adjusted to age at entry into the exposed cohort during the risk exposure period 1961–2001. The attributable fraction (AF) for DEE-related lung cancers will be calculated by province, sex, industry and occupation.

Results Approximately 1.4 million workers were exposed to DEE during the risk exposure period. The initial estimated AFs for DEE-related lung cancers are: 4.92% for males, 0.29% for females, and 2.70% overall.

Conclusions These burden estimates are somewhat higher than recent estimates from other groups (1.3–1.8%). They account for the most recent evidence for the risk of lung cancer from occupational DEE exposure, as well as detailed historical exposure assessment and labour force trends. Sensitivity analyses are underway to determine the influential assumptions.

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