Objectives Is the future in epigenetics?

Epigenetics investigates heritable changes in gene expression that occur without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation and histone modifications, can change genome function under exogenous influence. Results obtained from animal models indicate that in utero or early-life environmental exposures produce effects that can be inherited transgenerationally and are accompanied by epigenetic alterations. The search for human equivalents of the epigenetic mechanisms identified in animal models is in progress. I will present evidence from human environmental and occupational studies indicating that epigenetic alterations may mediate effects caused by toxic exposures. In these investigations, we have shown that exposures, including air pollution, lead, arsenic, nickel, and PAHs, are associated with altered methylation of human repetitive elements or genes. In recent preliminary studies, we have shown alterations of histone modifications and miRNAs in subjects exposed to metal-rich airborne particles. I will present original data demonstrating that altered DNA methylation in blood and other tissues is associated with potentially related disease, such as cardiovascular disease and asthma. On the basis of current evidence, I will propose possible models for the interplay between toxicants and the human epigenome.

Method Please see above.

Results Please see above.

Conclusions Please see above.