Article Text

Download PDFPDF

284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers
  1. D C Consonni1,
  2. Straif2,
  3. Symons3,
  4. Tomenson4,
  5. Amelsvoort Van5,
  6. Sleeuwenhoek6,
  7. Cherrie6,
  8. Bonetti7,
  9. Colombo7,
  10. Farrar8,
  11. Carugno9,
  12. Bertazzi9
  1. 1Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy
  2. 2International Agency for Research on Cancer, Lyon, France
  3. 3DuPont Epidemiology Program, E. I. du Pont de Nemours and Company, Newark, DE, United States of America
  4. 4Causation Ltd, Macclesfield, United Kingdom
  5. 5University of Maastricht, CAPHRI, Maastricht, The Netherlands
  6. 6Institute of Occupational Medicine, Edinburgh, United Kingdom
  7. 7Solvay Specialty Polymers Italy SpA, Bollate, Italy
  8. 8CCERT Ltd for Asahi Glass Company Chemicals Europe (AGCCE), Congleton, United Kingdom
  9. 9DISCCO, Università degli Studi di Milano, Milano, Italy


Objectives Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene (PTFE), increases liver and kidney cancer and leukaemia incidence in rats and mice. This is the first time the cancer risk in humans is comprehensively explored in a cohort mortality study.

Methods The study included all current PTFE production sites in Europe (Germany, Italy, The Netherlands and UK) and USA (New Jersey and West Virginia). The study cohort included workers ever employed in the period 1950–2002. A job-exposure matrix (1950–2002) was developed for TFE and ammonium perfluoro-octanoate (APFO), a chemical used in the polymerisation process. For each worker we calculated cumulative exposure to TFE and APFO. The mortality ascertainment covered the period 1950–2008. Standardised mortality ratios (SMR) and 95% confidence intervals (CI) were calculated using national mortality rates as reference.

Results Among 4,773 workers ever exposed to TFE, we found lower SMRs from most causes of death and increased SMRs for cancer of the liver (SMR 1.27; 95% CI: 0.55, 2.51; 8 deaths) and kidney (SMR 1.44; 95% CI: 0.69, 2.65; 10 deaths), and for leukaemia (SMR 1.48; 95% CI: 0.77, 2.59; 12 deaths). A non-significant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and APFO exposures were highly correlated, therefore their separate effects could not be disentangled.

Conclusions The pattern of findings in this large study substantially narrows the range of uncertainty on the possible cancer risk entailed by working in TFE synthesis and polymerisation, and justifies continuing efforts to minimise exposure, which has already dropped considerably over the years. However, the findings could neither conclusively confirm nor refute the hypothesis that TFE poses a carcinogenic risk to human beings. If a cancer hazard exists, then the risk is small, even in workers with relatively high exposure.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.