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381 Endocrine disruptors and the risk of lymphoma in the Epilymph study
  1. L C Costas1,
  2. Infante-Rivard2,
  3. Cocco3,
  4. van Tongeren4,
  5. Zock5,
  6. de Sanjosé1
  1. 1Catalan Institute of Oncology, Barcelona, Spain
  2. 2McGill University, Montreal, Canada
  3. 3University of Cagliari, Cagliari, Italy
  4. 4Institute of Occupational Medicine, Edinburgh, United Kingdom
  5. 5Centre for Research in Environmental Epidemiology, Barcelona, Spain


Objectives Some industrial chemicals and pesticides might have endocrine disrupting effects. While some pesticides and solvents have been associated with an increased risk of lymphoma, whether this would be the result of their potential endocrine disrupting effect has not been investigated as yet. We explored the role of occupational exposure to endocrine disruptors in lymphoma aetiology.

Methods The Epilymph study is a multicenter case-control study carried out in six European countries from 1998 to 2004. We evaluated 2,457 controls and 2,013 lymphoma cases and its subtypes. Information on occupational history was collected through face-to-face interviews. We applied a job-exposure matrix (JEM) for endocrine disrupting chemicals to assess occupational exposures (Brouwers et al. 2009). We evaluated exposure to ten chemical groups: polycyclic aromatic hydrocarbons, polychlorinated organic compounds, pesticides, phthalates, solvents, bisphenol-A, alkylphenolic compounds, brominated flame retardants, metals and a miscellaneous group.

Results Prevalence of ever occupationally exposed among controls ranged from 1% (bisphenol-A) to 48% (solvents). Risks for non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukaemia (CLL) were increased with cumulative exposure to endocrine disruptors among men (OR = 1.20 CI95%:1.04–1.38 and 1.28 CI95%:1.01–1.61, respectively). However, none of the individual chemical groups evaluated was associated with NHL or follicular lymphoma risk. For other subtypes such as CLL, multiple myeloma, Hodgkin lymphoma and T-cell neoplasms risks were increased with several exposures, including metals (arsenic and copper), solvents (toluene and xylene), flame retardants, and ethylene glycol ethers.

Conclusions Some endocrine disruptors may play a role in the aetiology of certain lymphoma subtypes. Limitations in interpreting our findings include time- and country-related changes in exposure not reflected by the JEM, multiple comparisons and nondifferential misclassification leading to the attenuation of estimates for binary exposures.

Additional authors: Nikolaus Becker, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, Anthony Staines, Alexandra Nieters

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