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Original article
Work-related asthma in France: recent trends for the period 2001–2009
  1. Christophe Paris1,2,
  2. Joseph Ngatchou-Wandji1,
  3. Amandine Luc1,
  4. Roseanne McNamee3,
  5. Lynda Bensefa-Colas4,
  6. Lynda Larabi5,
  7. Maylis Telle-Lamberton6,
  8. Fabrice Herin2,
  9. Alain Bergeret7,
  10. Vincent Bonneterre8,
  11. Patrick Brochard9,
  12. Dominique Choudat4,
  13. Dominique Dupas10,
  14. Robert Garnier11,
  15. Jean-Claude Pairon12,13,
  16. Raymond M Agius3,
  17. Jacques Ameille14,
  18. the members of the RNV3P
  1. 1Inserm U954, Vandoeuvre Les Nancy, France
  2. 2Occupational Diseases Department, University Hospital, Nancy, France
  3. 3School of Community Based Medicine, The University of Manchester, Manchester, UK
  4. 4Occupational Health Department, Paris Descartes University, Sorbonne Paris Cité, AP-HP, Paris, France
  5. 5Occupational Health Department, University Hospital, Public Health Sector, Grenoble, France
  6. 6Agence Nationale de Sécurité Sanitaire (ANSES), Maisons-Alfort, USA
  7. 7Occupational Health Department, University Hospital, Lyon, France
  8. 8UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France
  9. 9Occupational Health Department, University Hospital, Bordeaux, France
  10. 10Occupational Health Department, University Hospital, Nantes, France
  11. 11Occupational Health Department, APHP, Denis Diderot University, Paris, France
  12. 12Inserm U 955, Occupational Health Department, University Hospital, Créteil, France
  13. 13Occupational Diseases Department, University Hospital, Creteil, France
  14. 14Occupational Health Department, AP-HP, Garches, France
  1. Correspondence to Professor Christophe Paris, Inserm Research Unit U954, 9 rue de la Foret de Haye, Vandoeuvre Les Nancy 54505, France;{at}


Objective Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001–2009.

Method Data were collected from the French national network of occupational health surveillance and prevention (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends.

Results Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p=0.007), aldehydes (p=0.01) and latex (p=0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p=0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure.

Conclusions WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.

  • Asthma
  • occupational exposure
  • statistical models
  • trend
  • work-related asthma
  • epidemiology
  • occupational asthma
  • cancer
  • retrospective exposure assessment
  • respiratory
  • cardiovascular
  • statistics
  • mortality studies
  • mathematical models
  • legal
  • occupational health practice
  • musculoskeletal
  • back disorders
  • preventive medicine
  • mineralogy
  • lung function
  • exposure assessment
  • cross-sectional studies
  • man-made mineral fibers
  • asbestos
  • silicosis
  • pneumoconioses
  • mesothelioma
  • allergy
  • OH services
  • male reproduction
  • health surveillance
  • clinical medicine
  • biological monitoring

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  • RNV3P members: Angers (Roquelaure Y., Petit A.), Amiens (Doutrellot-Philippon C.), Bobigny-Avicenne (Guillon F.), Besançon (Aptel M., Thiebaut A.), Bordeaux (Rinaldo M., Verdun-Esquer C.), Brest (Dewitte J.D., Lodde B.), Caen (Clin B., Marquignon M.F.), Cherbourg (Marquignon M.F.), Clermont-Ferrand (Chamoux A., Dutheil F.), Créteil (Pairon J.C., Andujar P.), Dijon (Smolik H.J.), Garches (Ameille J., d'Escatha A.), Grenoble (de Gaudemaris R., Bonneterre V.), Le Havre (Gislard A., Rollin L.), Lille (Frimat P., Nisse C.), Limoges (Druet-Cabanac M.), Lyon (Bergeret A., Normand J.C.), Marseille (Lehucher-Michel M.P.), Montpellier (Roulet A.), Nancy (Paris C., Penven E.), Nantes (Géraut C., Dupas D.), Paris-Cochin (Choudat D., Bensefa-Colas L.), Paris-Hôtel-Dieu (Léger D., Prevost Balensi E.), Paris-Fernand Widal (Garnier R., Villa A.), Poitiers (Ben-Brik E., Berson C.), Reims (Deschamps F., Lesage F.X.), Rennes (Verger C., Gouyet Ahu T.), Rouen (Gehanno J.F.), Saint-Etienne (Fontana L., Pélissier C.), Strasbourg (Cantineau A., Nourry N.), Toulouse (Soulat J.M., Hérin F.), Tours (Lasfargues G., Haguenoer K.).

  • Funding This network was funded by the French Agency for Food, Environmental and Occupational Health & Safety (Anses), the National Health Insurance system for employees (CNAM-TS), the French Occupational Medicine Society (SFMT), the National health insurance system for agricultural workers (CCMSA) and the French Institute for Public Health Surveillance (InVS).

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Agence Nationale de Sécurité Sanitaire, Alimentation, Environnement, Travail.

  • Provenance and peer review Not commissioned; externally peer reviewed.