Article Text

Workplace interventions for treatment of occupational asthma: a Cochrane systematic review
  1. G J de Groene,
  2. T M Pal,
  3. J Beach,
  4. S M Tarlo,
  5. D Spreeuwers,
  6. M H W Frings-Dresen,
  7. S Mattioli,
  8. J H Verbeek
  1. Netherlands Center of Occupational Diseases, Academic Medical Center, Amsterdam, The Netherlands
  1. Correspondence to G J de Groene, Netherlands Center of Occupational Diseases, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands; g.j.degroene{at}

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Occupational asthma is the most frequently reported work-related respiratory disease in many countries. It is defined as asthma that is caused by a specific workplace exposure to certain substances and not to factors outside the workplace. In a recent review, the population attributable risk for adult onset asthma being caused by occupational exposures was 17.6%. Occupational asthma can lead to decreased quality of life, sickness absence and increased costs for the patient, the employer and society. Common causes of occupational asthma include exposure to high molecular weight (HMW) agents such as wheat, latex and animal proteins, or to low molecular weight (LMW) agents such as di-isocyanates, acid anhydrides, platinum salts and plicatic acid. There are no systematic reviews of controlled studies of workplace interventions for occupational asthma. Therefore, we conducted a Cochrane systematic review to evaluate the effectiveness of workplace interventions on the outcome of occupational asthma.1


We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, NIOSHTIC-2, CISDOC and HSELINE up to February 2011.

We intended to include randomised controlled trials, controlled before and …

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