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Occupational exposure to crack detection dye penetrants and the potential for bladder cancer
  1. Aidan P Noon1,
  2. Simon M J Pickvance2,
  3. James W F Catto1,3
  1. 1Department of Urology, Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK
  2. 2School for Health and Related Research, University of Sheffield, Sheffield, UK
  3. 3Institute for Cancer Studies, Academic Urology Unit, University of Sheffield, Sheffield, South Yorkshire, UK
  1. Correspondence to Dr James W F Catto, Institute for Cancer Studies, G Floor, The Medical School, University of Sheffield, Beech Hill Road, Sheffield, South Yorkshire S10 2RX, UK; j.catto{at}

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We have been interested in occupational bladder cancer (urothelial cell carcinoma (UCC)) and most specifically the disease in patients from the steel and metal industries. With this in mind, we conducted a prospective evaluation of newly diagnosed patients located geographically within a region that is rich in steel and metal industries. We present a case series of newly diagnosed patients who share an occupational task history of metal crack or fatigue testing. We suspect that this task may cause UCC as there was an unusual pathological distribution of these tumours; they were often multifocal at presentation, there was an absence of other carcinogens (including smoking), the latency between exposure and disease was typical for occupational UCC and because crack detection agents included potential urothelial carcinogens.

We …

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  • Ethics approval This study was approved by the South Sheffield Regional Ethics Board (ssrec 00/083).

  • Provenance and peer review Not commissioned; internally peer reviewed.