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Predicting chemicals causing cancer in animals as human carcinogens
  1. James Huff
  1. Correspondence to National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; huff1{at}

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Further to the posit by Suarthana et al (Occup Environ Med 2009;66:713–14) for predicting occupational diseases, long-term carcinogenesis bioassays using experimental animals are the most predictive method for identifying likely human carcinogens. Since the 1960s, bioassays have proven a mainstay for identifying chemical carcinogens, establishing occupational exposure standards, and primary cancer prevention. The reasons, rationale, and validity are many. Most importantly, long-term bioassays are both predictive (prospective) and confirmatory (retrospective) for human carcinogens.

Historically there has long been an agreeable association between carcinogenic outcomes from bioassays and human cancer hazards.1 2 These correlations stem from accumulated evidence over the last 50 years during the modern era of experimental carcinogenesis. …

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  • Funding National Institute of Environmental Health Sciences Other Funders: NIH.

  • Competing interests None.

  • Provenance and peer review Not commissioned; not externally peer reviewed.