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Cause-specific mortality of Dutch chlorophenoxy herbicide manufacturing workers
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  • Published on: 2 March 2010
    Response to Boers et al: request for additional results on cardiovascular disease

    We read with great interest the recent publication by Boers et al (2010), in which they presented updated mortality results from an occupational cohort of Dutch chlorophenoxy herbicide manufacturing workers. The previous follow-up from this cohort (Hooiveld et al, 1998) reported a statistically significant dose-related increase in mortality from ischemic heart disease (IHD) with increasing levels of modeled TCDD exposur...

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    Conflict of Interest:
    None declared.
  • Published on: 13 January 2010
    Effects of phenoxy acid herbicides

    Dear Editor,

    This carefully conducted study (1) points at the kidney as a potential target of toxicity of phenoxy acids in a chronic occupational exposure.

    This is biologically plausible as the phenoxy acids are inhibitors of chloride channels in renal tubular cells (2) which leads to alterations in the excretion of urinary electrolytes (3).

    Thus, it is entirely possible that the chronic dysfun...

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    Conflict of Interest:
    None declared.