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Disease severity, self-reported experience of workplace discrimination and employment loss during the course of chronic HIV disease: differences according to gender and education
  1. R Dray-Spira1,2,
  2. A Gueguen1,2,
  3. F Lert1,2,
  4. the VESPA Study Group*
  1. 1
    INSERM, U687, Villejuif, France
  2. 2
    Université Paris XI, IFR69, Villejuif, France
  1. Dr R Dray-Spira, INSERM U687, Hôpital Paul Brousse, 16 av. Paul Vaillant Couturier, 94807 Villejuif Cedex, France; r.dray{at}


Objectives: Evidence for the existence of a harmful effect of chronic disease on employment status has been provided. Although this effect of chronic illness on employment has been reported to be higher among the groups with the lowest position on the labour market, the mechanisms of such inequalities are poorly understood. The present study aimed at investigating social inequalities in the chances of maintaining employment during the course of HIV infection and at examining the correlates of such inequalities.

Methods: The authors used data from a national representative sample of people living with HIV in France (ANRS-EN12-VESPA survey). Retrospective information on social trajectory and disease characteristics from the time of HIV diagnosis was available. The risk of employment loss associated with indicators of disease severity and HIV-related workplace discrimination was computed over time since HIV diagnosis according to sociodemographic and occupational factors, using Cox proportional hazards models.

Results: Among the 478 working-age participants diagnosed as being HIV-infected in the era of multitherapies and employed at the time of HIV diagnosis, 149 experienced employment loss. After adjusting for sociodemographic and occupational factors, disease severity and self-reported HIV-related discrimination at work were significantly associated with the risk of employment loss in a socially-differentiated manner: advancement in HIV disease was associated with an increased risk of employment loss among women (HR 4.45, 95% CI 2.10 to 9.43) but not among men; self-reported experience of HIV-related discrimination at work was associated with an increased risk of employment loss among individuals with a primary/secondary educational level (HR 8.85, 95% CI 3.68 to 21.30) but not among those more educated.

Conclusions: Chronic HIV disease affects the chances of maintaining employment in a socially-differentiated manner, resulting in increasing inequalities regarding workforce participation. Disease severity and workplace HIV-related discrimination, particularly affecting the employment status of the most socioeconomically disadvantaged, may play a major role.

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  • *The VESPA study group includes: A D Bouhnik (INSERM U379/ORS PACA), R Dray-Spira (INSERM U687-IFR69), J Fagnani (CNRS-UMR Matisse), I Heard (INSERM U430, Hôpital Européen Georges Pompidou), F Lert (INSERM U687-IFR69), Y Obadia (ORS PACA/INSERM U379), P Peretti-Watel (ORS PACA/INSERM U379), J Pierret (CERMES-INSERM U750-CNRS UMR 8559), B Riandey (INED), M A Schiltz (CERMES-INSERM U750-CNRS UMR 8559), R Sitta (INSERM U687-IFR69), B Spire (INSERM U379/ORS PACA).

  • Funding: The ANRS-EN12-VESPA study was funded by the ANRS (Agence Nationale de Recherche sur le Sida et les Hépatites Virales).

  • Competing interests: None.