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202 FARMING EXPOSURE AND EARLY-ONSET PROSTATE CANCER
To examine the hypotheses that early-onset prostate cancer are associated with age specific general farming exposures and exposure to triazine herbicides.
A population-based case-control study of prostate cancer recruited all early-onset cases (diagnosed under age 60; n = 1198) and 10% of late-onset cases (diagnosed age 60–79; n = 385) from Minnesota and Wisconsin state cancer registries. Controls were selected from state drivers’ license/ID records and frequency matched by age. In-person interviews ascertained history of living or working on a farm or ranch, specific pesticide exposures, demographic information, lifestyle, medical history, and family history of cancer. Total fat intake came from a self-administered food frequency questionnaire. A cumulative triazine exposure index was based on the number of applications per year and years of application of all triazine chemicals. General farming exposures from living or working on a farm were classified as exposure only as a child, as a child and an adult, and only as an adult. Odds ratios (OR) and 95% confidence intervals (CI) for early and late onset prostate cancer were estimated using a logistic regression controlling for potential confounders.
Compared to men who reported no farming exposure, the risk of early-onset prostate cancer was not associated with living or working on a farm only as a child (OR 0.97, 95% CI 0.78 to 1.19) or as a child and an adult (0.86, 95% CI 0.72 to 1.16), but may be lower when exposed only as an adult (OR 0.61, 95% CI 0.37 to 1.02). Risk of later onset prostate cancer was associated with childhood-only exposure (OR 1.43, 95% CI 1.02 to 2.00), but not exposure as an adult and child (OR 1.04, 95% CI 0.72 to 1.50) or only as an adult (OR 0.61, 95% CI 0.24 to 1.57). Compared to men with no triazine exposure, the risk of early-onset prostate …