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176 OCCUPATION AND EXPOSURE TO PESTICIDES AND SOLVENTS AND THE RISK OF BRAIN TUMOURS: A UK CASE-CONTROL STUDY
To investigate whether certain occupations and exposure to solvents and pesticides are associated with an increased risk of developing glioma, meningioma and acoustic neuroma.
A population based case-control study was conducted in four regions in the UK: Trent, West Midlands, West Yorkshire and central Scotland. Occupational histories were collected from all participants, whilst detailed information on pesticide and solvent exposure was collected from most of the controls and about half of the cases. Occupational exposure to solvents and pesticides was determined based on the information provided in the questionnaire by a team of experts. Occupations were selected a priori for analyses based on information from the literature.
Data were obtained from 2078 eligible participants: 978 cases of brain tumours (gliomas n = 593; meningiomas n = 250; acoustic neuromas n = 135) and 1100 controls. Agricultural or related work was statistically significantly associated with an increased risk of developing meningioma (OR 2.0, 95% CI 1.1 to 3.5); no other occupations were associated with increased risk. No associations were observed between any occupations and glioma or acoustic neuroma. For exposure to solvents or pesticides, no significant ORs were observed for any type of brain tumour.
The results of this study suggest that working in agriculture or related sectors is associated with an increased risk of developing meningioma but not glioma or acoustic neuroma. However, no association was observed with occupational pesticide or solvent exposure.
brain tumour; epidemiology; occupation
177 CANCER ADMISSION AND MORTALITY IN RADIATION WORKERS IN KOREA
Surveillance for exposure to low levels of ionising radiation has been conducted for Korean workers since 1983. The cancer mortality and morbidity experience of these workers is described for the first time in Korea.
Cancer mortality from 1992 to 2004 was analysed in a large Korean National Dose Registry cohort with individual annual dosimetry from 1 January 1983 to 31 December 2004. The comparison group was workers in motor …