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135 OCCUPATIONAL EXPOSURE TO ENDOCRINE DISRUPTING COMPOUNDS AND BILIARY TRACT CANCER IN MEN
This study investigates the association between extrahepatic biliary tract (EBT) cancer and exposure to endocrine disrupting compounds (EDCs).
183 men with histologically confirmed carcinoma of the EBT and 1938 matched controls were interviewed between 1995 and 1997 in the frame of an international multi-centre case-control study in six European countries (Denmark, France, Germany, Italy, Spain and Sweden). Self-reported job descriptions were converted into primary quantification variables (intensity, probability and duration of the exposure) for 14 EDCs. Cases were compared with 1421 population controls and 517 colon adenocarcinoma patients. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from unconditional logistic regression and adjusted for age, country and gallstones.
Occupational exposure to EDCs resulted in an OR of 1.4 (95% CI 0.9 to 2.1) with an inconsistent dose–effect relationship for cumulative exposure (low: OR 1.2, 95% CI 0.6 to 2.3; medium: OR 1.8, 95% CI 1.0 to 3.4; high: OR 1.5, 95% CI 0.9 to 2.7) (only index subjects). The adjusted OR for EBT cancer after exposure to PCBs was 2.3 (95% CI 1.1 to 4.8; only index subjects). None of the other agents considered revealed a similar association with EBT cancer.
Our findings do not show a convincing association between exposure to EDCs in the workplace and the risk for EBT cancer in men. However, among the agents of interest PCBs could possibly be a strong risk factor.
case-control study; extrahepatic bile duct carcinoma; xenoestrogens
136 URANIUM WORKERS AND CANCER RISK: A CRITICAL REVIEW WITH EMPHASIS ON INTERNAL EXPOSURE
Workers involved in the nuclear fuel cycle have a potential of internal exposure to uranium. The objective of this article is to conduct a critical review of epidemiological results currently available concerning the relationship between occupational internal exposure to uranium compounds and the risk of cancer.
Epidemiological studies on workers with a potential for internal exposure to uranium published since 1980 were searched using …