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127 RESPIRATORY SEQUELAE FOLLOWING A FIRE AT A CHEMICAL WASTE DEPOT
In May 2000 480 tons of chemical waste were burnt at a hazardous waste disposal site and dispersed smoke and other combustion products over a large area to the west of the town of Drachten, The Netherlands. The objectives of this study are: first, to evaluate whether reactive airways dysfunction syndrome (RADS) occurs among the examined subjects; second, to evaluate if the RADS can be attributed to the ATF fire.
Because there was still concern among some of the public and workers involved in the incident, an aetiological study was undertaken in 2006. Because the results of a previously self-administered questionnaire demonstrated that RADS was a possible sequela of exposure to the smoke, the study focused on RADS and started with an interview by telephone using a standardised questionnaire. This was followed by a medical survey of 25 possible cases and 50 randomly sampled controls. Subjects meeting predefined criteria enrolled in a medical examination that consisted of spirometry, histamine challenge tests, laboratory tests and a chest x ray. In a subsample induced sputum has been assessed. Exposure was considered high if the distance to the fire was up to 100 m, intermediate from 100 to 1000 m and low beyond 1000 m.
Preliminary results show an odds ratio (95% CI) of 4.3 (1.5 to 11.8) for cases and controls of the interview. This odds ratio increased to 14.0 (2.8 to 70.8) when analysis was restricted to cases of lung physician diagnosis of possible RADS.
Indications were found of an association between exposure and respiratory symptoms indicative of RADS. The likelihood of selection and other biases will be discussed and balanced against the results of the medical survey.
respiratory effects; combustion products; police officers
128 A DIAGNOSTIC MODEL TO PREDICT THE PROBABILITY OF SENSITISATION TO WHEAT ALLERGENS AMONG BAKERS
In The Netherlands, the baking and flour producing industries agreed on developing a health surveillance system to …