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Reproductive 1 mini-symposium
  1. J. P. Bonde1,
  2. M. Rosenkilde1,
  3. G. Toft1,
  4. A. M. Thulstrup1,
  5. J. Olsen2
  1. 1Department of Occupational Medicine, Aarhus University Hospital
  2. 2University of California Los Angeles (UCLA)

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    Only a few occupational causes of miscarriage are known in spite of a large research effort in the past 20 years. True causative agents may escape recognition because of inadequate exposure assessment, limited study size and detection bias due to the fact that only a minority of conceptions survive to clinical detection. The objective of this study was to provide guidance for future research in the field by an overall assessment of risk for late miscarriage in the entire workforce.


    We analysed prospectively the collected data of 67 226 employed women who were enrolled into the Danish National Birth Cohort (DNBC) from 1997 through 2003. Information on work during pregnancy was obtained by telephone interview around the 16th week of gestation. Job titles were classified according to the International Standard Classification of Occupations (ISCO-88). Data on miscarriage were obtained by linkage to the National Hospital Register. Hazard ratios (HRs) of late miscarriage by occupation classified at the ISCO-88 four-digit level with 308 occupations were computed by proportional hazard regression taking a fixed set of covariates and time at risk into account. For each occupation the reference was all other occupations.


    The proportion of pregnant women who experienced a late fetal loss from the 16th week of gestation until and including the 28th week of gestation was 0.96%. Among the 125 occupations with at least one late miscarriage, we observed 15 occupations with increased HRs and two with decreased HRs at the 5% significance level. The corresponding figures at the 1% significance level were 5 and 0. None of the 10 most frequent occupations encompassing more than 1000 women including office workers, nurses, nurses aides, day-care workers, teachers and shop assistants had increased risk of late fetal loss.


    Our analyses of late fetal loss indicate that the search for occupational and thus …

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