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Chlorpyrifos exposure and biological monitoring among manufacturing workers
  1. C J Burns1,
  2. D Garabrant2,
  3. J W Albers3,
  4. S Berent4,
  5. B Giordani5,
  6. S Haidar1,
  7. R Garrison4,
  8. R J Richardson2
  1. 1The Dow Chemical Company, Department of Epidemiology, Midland, MI, USA
  2. 2University of Michigan, Department of Neurology, Ann Arbor, MI, USA
  3. 3University of Michigan, Department of Psychiatry, Ann Arbor, MI, USA
  4. 4University of Michigan, Department of Environmental Health Sciences, Ann Arbor, MI, USA
  5. 5University of Michigan, Department of Psychology, Ann Arbor, MI, USA
  1. Correspondence to:
 Dr C J Burns
 The Dow Chemical Company, Department of Epidemiology, 1803 Building, Midland, MI 48674, USA; cburns{at}


Aim: To use biological monitoring data to evaluate the soundness of job based exposure classifications.

Methods: The authors studied 52 chlorpyrifos manufacturing workers and 60 referent workers to compare chlorpyrifos exposure estimations from job titles and work areas to urinary excretion of 3,5,6 trichloro-2-pyridinol (TCP), a metabolite of chlorpyrifos. Work history records and industrial hygiene monitoring data were used to establish cumulative interim exposure. Chlorpyrifos exposure during the study year was assessed biologically by urinary excretion of TCP.

Results: Exposure as measured by three urinary TCP samples was significantly higher among the chlorpyrifos workers (188 μg/l) than it was for the referent subjects (7 μg/l). Urinary TCP also correlated well with specific exposure categories of negligible (0.73–1.98 mg/m3 days), low (1.99–4.91 mg/m3 days), and moderate (4.92–15.36 mg/m3 days). The weighted Kappa coefficient was 0.80 (95% CI 0.72 to 0.87) for the mean TCP over the study period.

Conclusions: The estimates of chlorpyrifos exposure based on job classifications and industrial hygiene measurements were significantly related to urinary TCP excretion, indicating that the ambient estimates are useful for providing exposure estimates among chlorpyrifos manufacturing workers.

  • BuChE, butyrylcholinesterase
  • SEG, similar exposure group
  • TCP, 3,5,6-trichloro-2-pyridinol
  • biomonitoring
  • clorpyrifos
  • exposure
  • trichloropyridinol

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  • Funding: Dow AgroSciences, LLC, and The Dow Chemical Company. C Burns and S Haidar are employed by The Dow Chemical Company.