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Can δ-aminolevulinic acid dehydratase 2 allele exert certain protective measures against the neurotoxic effects of lead?
  1. S-E Chia,
  2. E Yap,
  3. K-S Chia
  1. Department of Community, Occupational & Family Medicine (MD3), Faculty of Medicine, National University of Singapore, 16, Medical Drive, Singapore 117597, Republic of Singapore; cofcse@nus.edu.sg

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    Recently, there has been a lot of interest regarding δ-aminolevulinic acid dehydratase (ALAD) polymorphism and health effects of inorganic lead. Most of these reports focused on renal effects.1,2 There have been reports on the effects of lead on neurobehavioural function among exposed workers.3,4 As far as we know, only one paper has reported the effects of ALAD polymorphism and neurobehavioural testing. Bellinger et al studied 72 adolescents with high (>24 µg/g) and low (<8.7 µg/g) dentin lead levels. The results suggested that the body burden and effects of lead on neurobehavioural functions were worse among ALAD1 homozygotes.5

    We have carried out a cross-sectional study in 106 male workers exposed to low or moderate levels of inorganic lead in order to investigate the association between ALAD1 and ALAD2 genotypes and neurobehavioural functions. Blood and urine were collected for each …

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