Article Text

Download PDFPDF
Haematological effects among silk screening workers exposed to 2-ethoxy ethyl acetate
  1. C-H Loh1,
  2. T-S Shih2,
  3. S-H Liou3,
  4. Y-C Lin4,
  5. A-T Hsieh1,
  6. C-Y Chen2,
  7. G-D Liao3
  1. 1Department of Family Medicine & Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Nei-Hu, Taipei, Taiwan, ROC
  2. 2Institute of Occupational Safety and Health, Council of Labor Affairs, Shi-Jr, Taipei, Taiwan, ROC
  3. 3Department of Public Health, National Defense Medical Center, Nei-Hu, Taipei, Taiwan, ROC
  4. 4Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei, Taiwan, ROC
  1. Correspondence to:
 Dr C-H Loh, Department of Family Medicine, Tri-Service General Hospital, National Defense Medical Center, 325, Cheng-Kung Rd., Sec. 2, Nei-Hu, Taipei, Taiwan, 114, Republic of China; 


Background: 2-Ethoxy ethyl acetate (2-EEA) is a solvent with broad industrial and commercial applications. It has been reported to cause hematological toxicity, infertility, and teratogenesis.

Aims: To investigate the haematological effects in 2-EEA exposed workers.

Methods: Workers from one silk screening shop (n = 29), using 2-EEA as the major cleaning and printing solvent, were recruited as a high exposure group. Workers with indirect and non-exposure to 2-EEA (n = 56) were recruited as the comparison group. Venous blood was collected for blood routine examination. Air concentration of 2-EEA in this plant was measured by eight hour personal sampling.

Results: The geometric mean (GM) of air concentration of 2-EEA in the high exposure group was 7.41 ppm (range 1.35–16.5 pppm). The mean exposure of female workers (GM = 9.34 ppm) was significantly higher than that of male workers (GM = 4.87 ppm). The GM of air 2-EEA concentration in the comparison group was 0.07 ppm (range: non-detectable to 3.62 ppm, n = 26). The haemoglobin and haematocrit in the female high 2-EEA exposure workers were significantly lower than those of female workers in the comparison group. No difference was found between male 2-EEA high exposure and comparison group workers. The haemoglobin, haematocrit, and RBC count in the study population had a significant dose-response relation with air 2-EEA levels.

Conclusion: Results suggest that 2-EEA is a haematological toxicant, which leads to anaemic status in high exposure female workers.

  • 2-EEA
  • environmental monitoring
  • haematological toxicity
  • 2-EEA, 2-ethoxy ethyl acetate
  • EGE, ethylene glycol ether
  • GM, geometric mean
  • GSD, geometric standard deviation
  • MCH, mean corpuscular haemoglobin
  • MCHC, mean corpuscular haemoglobin concentration
  • MCV, mean corpuscular volume
  • MIBK, methyl isobutyl ketone
  • PEL, permissible exposure limit
  • RBC, red blood cells
  • TWA, time weighted average
  • WBC, white blood cells

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.