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Mortality in chemical workers potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) 1945–94: an update
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  • Published on:
    Re: Amyotrophic lateral sclerosis and occupational exposure to 2,4-D

    We appreciate the interest taken in our study by Dr. Freedman.[1] At the heart of the discussion are the interpretation of statistical significance in our study,[2] and the lack of statistical significance in others. A critical point in valuing causation is the weight of the evidence to be placed upon the nonsignificant increase of nonspecific exposures observed in human studies of amyotrophic lateral sclerosis (ALS) compare...

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    Conflict of Interest:
    None declared.
  • Published on:
    Amyotrophic lateral sclerosis and occupational exposure to 2,4-dichlorophenoxyacetic

    Editor

    Burns et al.[1] report a significant excess of deaths due to amyotrophic lateral sclerosis (ALS) in a cohort of Dow employees potentially exposed to the herbicide 2,4-Dichlorophenoxyacetic (2,4-D), but then argue against the plausibility of a causal association, concluding that the association "is not consistent with previous human or animal studies".

    This conclusion and the authors' characterisatio...

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    Conflict of Interest:
    None declared.