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Isocyanate exposure and occupational asthma: a case-referent study
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  • Published on:
    Re: Methodological problems in a case referent study based on a register of occupational asthma


    We are grateful to Dr Jarvolm for his comments on our paper. The specified aim of our study was to quantify the relationship between the level of occupational isocyanate exposure and risk of developing asthma. The usual approach to this problem is a cohort study in an exposed work force, possibly with a nested case referent analysis. A register based case referent study of the type described by Dr Jarvol...

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    Conflict of Interest:
    None declared.
  • Published on:
    Methodological problems in a case referent study based on a register of occupational asthma


    Meredith et al,[1] performed a case referent study to investigate asthma caused by isocyanates. They claimed that the results indicated that isocyanate asthma occurs at low 8h average exposure (around 1.5 ppb); for exposures above 1.125 ppb there was about a three fold increased risk, however this was of limited statistical significance (OR=3.2, 95% CI 0.96- 10.6; p=0.06). They also concluded that their s...

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    Conflict of Interest:
    None declared.