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Survey of symptoms, respiratory function, and immunology and their relation to glutaraldehyde and other occupational exposures among endoscopy nursing staff
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  • Published on:
    Re: Glutaraldehyde induced asthma in endoscopy nursing staff
    • A Vyas
    • Other Contributors:
      • "R McL Niven, CAC Pickering"


    Dr Burge and his coworkers raise a very important issue in terms of the physiological criteria on which a diagnosis of occupational asthma should be based, and in particular, the clinical significance of small work related declines in peak expiratory flow. We fully accept that a lack of an increase in diurnal variation does not exclude a diagnosis of occupational asthma. The pattern of peak flow measurements...

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    Conflict of Interest:
    None declared.
  • Published on:
    Glutaraldehyde induced asthma in endoscopy nursing staff


    We read with interest the paper on glutaraldehyde and symptoms in endoscopy nursing staff.[1] It is reported that there was an absence of objective evidence of the physiological changes associated with asthma. Peak expiratory flow (PEF) records from 17 cases were analysed by the Oasys 2 computer program, and three of these had Oasys-2 Scores >2.5. These cases were felt not to show asthma because PEF d...

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    Conflict of Interest:
    None declared.
  • Published on:
    Symptoms among endoscopy nursing staff

    The recent article by Vyas, et al.[1] raises some concerns to which I would be grateful if they could respond.

    1) In the abstract one of the objectives is stated as finding the nature and incidence of symptoms experienced by a large sample of hospital endoscopy nurses. The study design is cross-sectional and used an adapted version of the MRC questionnaire for respiratory symptoms. This study design normally re...

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    Conflict of Interest:
    None declared.