Article Text

Download PDFPDF
Biological effects of inhaled magnesium sulphate whiskers in rats.
  1. H Hori,
  2. T Kasai,
  3. J Haratake,
  4. S Ishimatsu,
  5. T Oyabu,
  6. H Yamato,
  7. T Higashi,
  8. I Tanaka
  1. Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, Kitakyushu, Japan.


    Male Wistar rats were exposed to two types of magnesium sulphate whiskers by inhalation for six hours a day, five days a week, for four weeks (sub-chronic study), or for one year (chronic study) to clarify the biological effects of the whiskers. There were few whiskers detected in the rat lungs even at one day after the exposure, suggesting that they are dissolved and eliminated rapidly from the lungs. To measure the clearance rate of the whiskers from the lungs, an intratracheal instillation was performed in golden hamsters. The half life of the whiskers in the lung was determined as 17.6 minutes by temporally measuring the magnesium concentration up to 80 minutes after the instillation. A histopathological examination indicated a frequent occurrence of adenoma and carcinoma in the year after chronic exposure, but it was not significantly different between exposed and control rats.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.