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Cor pulmonale and silicosis: a necropsy based case-control study.
  1. J Murray,
  2. G Reid,
  3. D Kielkowski,
  4. M de Beer
  1. National Centre for Occupational Health, Johannesburg, South Africa.


    The presence of cor pulmonale at death in relation to other factors such as emphysema, silicosis, and thromboembolism was analysed in a case-control study of 732 South African gold miners. Marked emphysema was the highest risk factor with an odds ratio of 21.32 (95% confidence interval (95% CI) 5.02-90.7), then extensive silicosis (OR 4.95, 95% CI 2.92-8.38) and thromboembolic disease (OR 1.92, 95% CI 1.37-2.69). Age and smoking were not significant predictors of cor pulmonale.

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