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Follow up study of renal tubular dysfunction and mortality in residents of an area polluted with cadmium.
  1. K Iwata,
  2. H Saito,
  3. M Moriyama,
  4. A Nakano
  1. Department of Preventive Medicine and Health Promotion, Nagasaki University School of Medicine, Japan.


    A retrospective cohort study was conducted to investigate the association between cadmium induced renal tubular dysfunction and mortality. A total of 230 subjects aged 40 or older and living in a cadmium polluted area in Kosaka Town, Akita Prefecture, Japan, were studied at least once between 1975 and 1977 and again in 1990. Urinary beta 2-microglobulin and total amino nitrogen concentrations were significantly related to mortality from all causes in women. The finding supports the idea that cadmium induced kidney damage is a factor associated with mortality in a general population exposed to environmental cadmium.

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