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Investigations for genotoxic effects after exposure to crude 2,4,5-trichlorophenol
  1. C E Blank1,
  2. Patricia Cooke2,
  3. A M Potter1
  1. 1Centre for Human Genetics, Sheffield, UK
  2. 2The Cytogenetics Department, The City Hospital, Nottingham, UK


    ABSTRACT An investigation was designed to look for chromosome irregularity, as an indication of genotoxic effect, in individuals accidentally exposed to crude 2,4,5-trichlorophenol 10 years earlier. Dioxin was a trace contaminant. Measurement of chromosome aberration and sister chromatid exchange rate, both of which might be expected to be increased in individuals exposed to substantial quantities of chemical mutagenic or carcinogenic agents, or both, showed no significant deviation from that expected by chance.

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