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A retrospective mortality study of substituted anthraquinone dyestuffs workers
  1. J S Gardiner,
  2. S A Walker,
  3. A J Maclean
  1. Organics Division, Imperial Chemical Industries Ltd, Blackley, Manchester M9 3DA, UK


    ABSTRACT Because short-term bacterial tests have previously shown that about one-third of substituted anthraquinones tested are capable of causing reverse mutation, and two-year feeding studies of three such dyestuffs in rats have shown an excess of hepatocellular carcinomas, a retrospective cohort mortality study was carried out on a population of 1975 male workers employed in a dyestuffs manufacturing plant in Scotland. The population was identified as having worked for more than six months within the factory during the decade 1 January 1956-31 December 1965, and their mortality experience was followed up to 30 June 1980. Age-standardised mortality rates did not show any excess in total or cancer-related mortality.

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